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Titolo:
Study on the reduction of chemotherapy induced neutropenia in mice using glucosaminylmuramyl dipeptide
Autore:
Armstrong, NA; Bolton, EJ; Morris, DL;
Indirizzi:
Univ New S Wales, St George Hosp, Dept Surg, Sydney, NSW 2217, Australia Univ New S Wales Sydney NSW Australia 2217 g, Sydney, NSW 2217, Australia
Titolo Testata:
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
fascicolo: 8, volume: 49, anno: 1999,
pagine: 716 - 720
SICI:
0004-4172(199908)49:8<716:SOTROC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; PHASE-I TRIAL; CANCER; RECOVERY;
Keywords:
CAS 78113-36-7; glucosaminylmuramyl dipeptide, effect on neutropenia, mouse; neutropenia, chemotherapy induced, experimental; romurtide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Morris, DL Univ New S Wales, St George Hosp, Dept Surg, Sydney, NSW 2217, Australia Univ New S Wales Sydney NSW Australia 2217 NSW 2217, Australia
Citazione:
N.A. Armstrong et al., "Study on the reduction of chemotherapy induced neutropenia in mice using glucosaminylmuramyl dipeptide", ARZNEI-FOR, 49(8), 1999, pp. 716-720

Abstract

Neutropenia is a common and often dose limiting side effect of some chemotherapy regimens. The aim of this study was to investigate the ability of animmunomodulator, glucosaminylmuramyl dipeptide (GMDP, CAS 78113-36-7, romurtide) to reduce chemotherapy induced neutropenia. BALB/c mice were treatedwith 200 mg kg(-1) cyclophosphamide (CY) to induce a reversible neutropenia lasting approximately 6-7 days. There was no change in the duration or depth of neutropenia in mice treated with GMDP for 3 consecutive days (2.5 or25 mg kg(-1)) starting the day after CY injection. In addition, at the doses used, the time of admmlstratlon of GMDP relative to CY did not alter this response. However, a marked neutrophilia compared to controls was consistently observed in all cases. Neutrophil counts of up to 14 times the baseline value were measured 6-7 days after the induction of neutropenia. GMDP had no effect in the absence of CY. Less variation was seen in white cell counts of older non-SPF mice treated with CY. When the activity of GMDP (5 mg kg(-1)) was compared with G-CSF (granulocyte colony stimulating factor, 100mu g kg(-1)) in these animals? GMDP showed a consistent trend to reduce the length of neutropenia, however, under the conditions tested only G-CSF treatment resulted in a significant reduction in the duration of neutropenia. In the 12-week-old mice, the neutrophilia seen with both G-CSF and GMDP was much smaller than in the 8-week-old mice, and was not significantly different from that in control mice treated with CY alone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 13:35:35