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Titolo:
Interleukin-6, nitric oxide, and the clinical and hemodynamic alterations of patients with liver cirrhosis
Autore:
Genesca, J; Gonzalez, A; Segura, R; Catalan, R; Marti, R; Varela, E; Cadelina, G; Martinez, M; Lopez-Talavera, JC; Esteban, R; Groszmann, RJ; Guardia, J;
Indirizzi:
Hosp Gen Univ Vall Hebron, Dept Internal Med, Liver Unit, Barcelona 08035,Spain Hosp Gen Univ Vall Hebron Barcelona Spain 08035 t, Barcelona 08035,Spain Hosp Gen Univ Vall Hebron, Dept Biochem, Barcelona, Spain Hosp Gen Univ Vall Hebron Barcelona Spain ept Biochem, Barcelona, Spain Yale Univ, W Haven, CT USA Yale Univ W Haven CT USAYale Univ, W Haven, CT USA Vet Affairs Med Ctr, W Haven, CT USA Vet Affairs Med Ctr W Haven CT USAVet Affairs Med Ctr, W Haven, CT USA
Titolo Testata:
AMERICAN JOURNAL OF GASTROENTEROLOGY
fascicolo: 1, volume: 94, anno: 1999,
pagine: 169 - 177
SICI:
0002-9270(199901)94:1<169:INOATC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PORTAL-HYPERTENSIVE RATS; TUMOR-NECROSIS-FACTOR; HYPERDYNAMIC CIRCULATION; FACTOR-ALPHA; VASCULAR HYPORESPONSIVENESS; BACTERIAL TRANSLOCATION; L-ARGININE; NITRATE; INHIBITION; CYTOKINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Genesca, J Hosp Gen Univ Vall Hebron, Dept Internal Med, Liver Unit, Passeig Vall Hebron 119, Barcelona 08035, Spain Hosp Gen Univ Vall Hebron Passeig Vall Hebron 119 Barcelona Spain 08035
Citazione:
J. Genesca et al., "Interleukin-6, nitric oxide, and the clinical and hemodynamic alterations of patients with liver cirrhosis", AM J GASTRO, 94(1), 1999, pp. 169-177

Abstract

Objective: Nitric oxide has been proposed as a mediator of hyperdynamic circulation in cirrhosis. Endotoxin and cytokines induce the synthesis of nitric oxide. The aim of this study was to investigate the relationship between endotoxemia, cytokines, and nitric oxide in patients with cirrhosis, and to correlate these findings with clinical, biochemical, and hemodynamic parameters. Methods: Clinical, biochemical, and hemodynamic parameters were assessed in 66 patients with cirrhosis and 15 controls. Levels of antidiuretic hormone, plasma renin activity, aldosterone, interferon gamma, interleukin-l, interleukin-6, tumor necrosis factor alpha, endotoxin, and nitrates-nitrites were determined. Results: Mean arterial pressure was lower and interleukin-6, tumor necrosis factor alpha, nitrites-nitrates levels, and endotoxin positivity rates were higher in cirrhotics than in controls (p < 0.005). Mean arterial pressure decreased and interleukin-6 levels increased with worsening of Child score (p < 0.005). Patients with ascites had higher levels of interleukin-6, tumor necrosis factor alpha, and nitrates-nitrites than patients without ascites (p < 0.01). Elevated levels of interleukin-6 were found in patients with encephalopathy grade I, compared with patients without (p, < 0.001); this association was independent of the severity of liver disease. II patients with low mean arterial pressure, interleukin-6 levels were higher than in patients with high mean arterial pressure (p = 0.001), whereas tumor necrosis factor a and nitrates-nitrites levels were not different. By multivariate analysis, high interleukin-6 levels showed independent associations with the presence of ascites, encephalopathy, and low meanarterial pressure. Only interleukin-6 levels had significant correlations with Child score, plasma renin activity, serum and urinary sodium, and meanarterial pressure (r greater than or equal to 0.4, p < 0.005). Conclusions: Although the activity of the nitric oxide pathway is increased in patients with cirrhosis and might contribute to the hemodynamic alteration, other factors are involved. Interleukin-6, possibly through nitric oxide-independent mechanisms, also might play a role in the vasodilatation of cirrhosis and the pathogenesis of hepatic encephalopathy. (C) 1999 by Am. Cell. of Gastroenterology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 11:11:24