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Titolo:
Increased expression of the CD11b/CD18 antigen on the surface of peripheral white blood cells in patients with ischemic heart disease: Further evidence for smoldering inflammation in patients with atherosclerosis
Autore:
Kassirer, M; Zeltser, D; Prochorov, V; Schoenman, G; Frimerman, A; Keren, G; Shapira, I; Miller, H; Roth, A; Arber, N; Eldor, A; Berliner, S;
Indirizzi:
Sackler Fac Med, Dept Internal Med D, Tel Aviv Sourasky Med Ctr, IL-64239 Tel Aviv, Israel Sackler Fac Med Tel Aviv Israel IL-64239 Ctr, IL-64239 Tel Aviv, Israel Sackler Fac Med, Dept Cardiol, Tel Aviv Sourasky Med Ctr, Tel Aviv, IsraelSackler Fac Med Tel Aviv Israel Aviv Sourasky Med Ctr, Tel Aviv, Israel Sackler Fac Med, Dept Gastroenterol, Tel Aviv Sourasky Med Ctr, Tel Aviv, Israel Sackler Fac Med Tel Aviv Israel Aviv Sourasky Med Ctr, Tel Aviv, Israel Sackler Fac Med, Dept Hematol, Tel Aviv Sourasky Med Ctr, Tel Aviv, IsraelSackler Fac Med Tel Aviv Israel Aviv Sourasky Med Ctr, Tel Aviv, Israel
Titolo Testata:
AMERICAN HEART JOURNAL
fascicolo: 3, volume: 138, anno: 1999,
parte:, 1
pagine: 555 - 559
SICI:
0002-8703(199909)138:3<555:IEOTCA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-REACTIVE PROTEIN; MONOCYTE ADHESION MOLECULES; ACUTE CORONARY SYNDROMES; UNSTABLE ANGINA; ARTERY DISEASE; LEUKOCYTE; NEUTROPHIL; RISK; ACTIVATION; EVENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Berliner, S Sackler Fac Med, Dept Internal Med D, Tel Aviv Sourasky Med Ctr, 6 WeizmanSt, IL-64239 Tel Aviv, Israel Sackler Fac Med 6 Weizman St Tel Aviv Israel IL-64239 Israel
Citazione:
M. Kassirer et al., "Increased expression of the CD11b/CD18 antigen on the surface of peripheral white blood cells in patients with ischemic heart disease: Further evidence for smoldering inflammation in patients with atherosclerosis", AM HEART J, 138(3), 1999, pp. 555-559

Abstract

Background This study examined the availability of the CD11b/CD18 and CD62L antigens on the surface of peripheral blood leukocytes in patients with ischemic heart disease. Methods and Results The study population included 45 patients with angiographically documented ischemic heart disease admitted to our department of internal medicine and the cardiology department during 1 month (December 1997). Sixty-six healthy members of the hospital medical staff served as control subjects. Another 39 post-trauma patients who were admitted to the emergency room were also evaluated. Patients with ischemic heart disease had significantly (P < .002) higher concentrations of CD11b/CD18 antigen on the surface of their polymorphonuclear leukocytes and monocytes (mean fluorescence intensity of 203 +/- 81 and 261 +/- 75, respectively) compared with the control group (mean fluorescence intensity 158 +/- 68 and 211 +/- 74, respectively) and to the group of patients with acute stress (mean fluorescence intensity of 146 +/- 70 and 200 +/- 22, respectively). CONCLUSIONS The presence of increased concentration of CD11b/CD18 suggeststhat circulating leukocytes ore activated in patients with ischemic heart disease. This activation probably reflects the presence of an inflammatory response involving the atherosclerotic lesion and is not merely a result ofacute stress.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:19:22