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Titolo:
Neuroprotective properties of statins in cerebral ischemia and stroke
Autore:
Vaughan, CJ; Delanty, N;
Indirizzi:
Cornell Univ, Dept Med, Weill Med Coll, New York Presbyterian Hosp,Div Cardiol, New York, NY 10021 USA Cornell Univ New York NY USA 10021 sp,Div Cardiol, New York, NY 10021 USA Hosp Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA Hosp Univ Penn Philadelphia PA USA 19104 urol, Philadelphia, PA 19104 USA
Titolo Testata:
STROKE
fascicolo: 9, volume: 30, anno: 1999,
pagine: 1969 - 1973
SICI:
0039-2499(199909)30:9<1969:NPOSIC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; COA REDUCTASE INHIBITORS; LIPID-PEROXIDATION; CHOLESTEROL LEVELS; ENDOTHELIAL-CELLS; SERUM-CHOLESTEROL; BRAIN INJURY; MICE LACKING; HYPERCHOLESTEROLEMIA; PRAVASTATIN;
Keywords:
endothelium; HMG-CoA reductase inhibitors; inflammation; nitric oxide; neuroprotection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Vaughan, CJ Cornell Univ, Dept Med, Weill Med Coll, New York Presbyterian Hosp,Div Cardiol, Starr 4,525 E 68th St, New York, NY 10021 USA Cornell Univ Starr 4,525 E 68th St New York NY USA 10021 1 USA
Citazione:
C.J. Vaughan e N. Delanty, "Neuroprotective properties of statins in cerebral ischemia and stroke", STROKE, 30(9), 1999, pp. 1969-1973

Abstract

Background-The atheroma-retarding properties of beta-hydroxy-beta-methylglutaryl coenzyme A reductase (HMG-CoA) inhibitors, or "statins," in both thecoronary and carotid arterial beds are well established. However, a growing body of recent data suggests that statins possess important adjunctive properties that may confer additional benefit beyond the retardation of atherosclerosis. In this article, we review the emerging evidence that statins have beneficial effects within the cerebral circulation and brain parenchymaduring ischemic stroke and reperfusion. Summary of Review-Clinical studies show that statins reduce the incidence of ischemic stroke through probable effects on precerebral atherosclerotic plaque and through antithrombotic mechanisms. Additionally, statins have been shown to reduce infarct size in experimental animal models of stroke. Statins both upregulate endothelial nitric oxide synthase (eNOS) and inhibit inducible nitric oxide synthase (iNOS), effects that are potentially neuroprotective. The preservation of eNOS activity in cerebral vasculature, particularly in the ischemic penumbra, may be especially important in preservingblood flow and limiting neurological loss. Statins may also attenuate the inflammatory cytokine responses that accompany cerebral ischemia, and they possess antioxidant properties that likely ameliorate ischemic oxidative stress in the brain. Conclusions-In addition to reducing stroke, the statin class of drugs exhibits a number of important neuroprotective properties that likely attenuatethe effects of ischemia on the brain vasculature and parenchyma. Further investigation of the role of statins in human neuroprotection by use of neuroimaging and cognitive studies is warranted to explore these preliminary observations. In addition to reducing ischemic stroke, early evidence indicates that statins may also be neuroprotective.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 11:22:03