Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Clinical application of asymptomatic embolic signal detection in acute stroke - A prospective study
Autore:
Kaposzta, Z; Young, E; Bath, PMW; Markus, HS;
Indirizzi:
Inst Psychiat, Dept Clin Neurosci, London SE5 8AF, England Inst Psychiat London England SE5 8AF n Neurosci, London SE5 8AF, England Guys Kings & St Thomas Hosp, Sch Med, Dept Clin Neurosci, London, England Guys Kings & St Thomas Hosp London England in Neurosci, London, England Guys Kings & St Thomas Hosp, Sch Med, Dept Med, London, England Guys Kings& St Thomas Hosp London England d, Dept Med, London, England
Titolo Testata:
STROKE
fascicolo: 9, volume: 30, anno: 1999,
pagine: 1814 - 1818
SICI:
0039-2499(199909)30:9<1814:CAOAES>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MIDDLE CEREBRAL-ARTERY; TRANSCRANIAL DOPPLER; MICROEMBOLIC SIGNALS; CAROTID ENDARTERECTOMY; ULTRASOUND; DISEASE; ISCHEMIA; STENOSIS; MODEL;
Keywords:
cerebral embolism; stroke; ultrasonography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Markus, HS Inst Psychiat, Dept Clin Neurosci, De Crespigny Pk, London SE5 8AF, England Inst Psychiat De Crespigny Pk London England SE5 8AF , England
Citazione:
Z. Kaposzta et al., "Clinical application of asymptomatic embolic signal detection in acute stroke - A prospective study", STROKE, 30(9), 1999, pp. 1814-1818

Abstract

Background and Purpose-The detection of asymptomatic embolization with theuse of Doppler ultrasound has a number of potential applications in patients with acute stroke. It may provide information on the stroke pathogcncsisin individual cases, identify patients with continued embolization, and allow localization of the active embolic source. Methods-We recruited 119 patients with acute anterior circulation infarction within 72 hours of stroke: onset. Transcranial Doppler recordings were possible in 100 (84.0%). Bilateral I-hour middle cerebral artery (MCA) recordings were made and saved on digital audiotape for blinded offline analysis. When embolic signals were detected during screening of the first recording, simultaneous recording was performed from the ipsilateral MCA and commoncarotid artery for an additional 30 minutes. In all patients with embolic signals at screening and in matched negative controls, recordings were repeated on days 4, 7, and 14. Results-Embolic signals were detected in the symptomatic MCA in 16 patients (16%). They were more common in patients with carotid stenosis (P<0.0001), occurring in 50% of this group. They were rare in patients with cardioembolic stroke (4.5%) and were not detected in patients with lacunar stroke. In the 16 patients with embolic signals, the proportion with embolic signalsfell over time (P=0.0025), but they were still present in a third at 2 weeks. In 10 patients, localization of the embolic source was possible by simultaneous recording from the MCA and the ipsilateral common carotid artery. Conclusions-Continued asymptomatic embolization is common after stroke in patients with carotid artery disease and is still present in a significant proportion at 2 weeks. The technique may identify patients at risk of further stroke for more aggressive antiplatelet therapy; this needs to be testedin large prospective studies. The technique may also allow localization ofthe active embolic source.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:18:51