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Titolo:
Relationship between serum leptin and obesity
Autore:
Mattit, HA; Kabalan, YM; Al Quobaili, FA;
Indirizzi:
Assad Univ Hosp, Dept Clin Lab, Damascus, Syria Assad Univ Hosp DamascusSyria niv Hosp, Dept Clin Lab, Damascus, Syria Assad Univ Hosp, Dept Endocrinol, Damascus, Syria Assad Univ Hosp Damascus Syria v Hosp, Dept Endocrinol, Damascus, Syria Damascus Univ, Fac Pharm, Dept Biochem & Microbiol, Damascus, Syria Damascus Univ Damascus Syria Dept Biochem & Microbiol, Damascus, Syria
Titolo Testata:
SAUDI MEDICAL JOURNAL
fascicolo: 8, volume: 20, anno: 1999,
pagine: 605 - 609
SICI:
0379-5284(199908)20:8<605:RBSLAO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
OB GENE; ADIPOSE-TISSUE; MESSENGER-RNA; EXPRESSION; WEIGHT; CLONING; HYPOTHALAMUS; PROTEIN; HUMANS; RATS;
Keywords:
obesity; body mass index; waist hip ratio; hormones; sex and age related effects;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Mattit, HA POB 11667, Damascus, Syria POB 11667 Damascus SyriaPOB 11667, Damascus, Syria
Citazione:
H.A. Mattit et al., "Relationship between serum leptin and obesity", SAUDI MED J, 20(8), 1999, pp. 605-609

Abstract

Objective: Leptin, the product of the ob gene, is a hormone secreted by adipocytes. This study aimed to measure serum concentrations of leptin in normal - weight subjects (body mass index between 18 and 25) and obese subjects (body mass index greater than or equal to 30). It is designed to support an important role for leptin in human metabolism and obesity,Methods: One hundred lean subjects aged (33.16 +/- 12.47) years and 193 obese subjects aged (38.6 +/- 13.5) years, and 73 obese non-insulin dependentdiabetes aged (51.9 +/- 9.6) years were included in the study, where as obesity was defined as a body mass index greater than or equal to 30 serum leptin concentrations were measured using a newly developed radioimmunoassay. Results: The mean +/- SD serum leptin concentrations were 25.99 +/- 15.4 ng per milliliter in the obese subjects and 5.84 +/- 5.27 ng per milliliter in the normal weight subjects (P less than or equal to 0.001). Serum leptinconcentrations in specimens from lean and obese adults correlated directlywith body mass index (body mass index; Kg/m(2)) (r = 0.74, P less than or equal to 0.001). Correlations were significantly improved by separating results by gender (men r = 0.85, women r = 0.72; P less than or equal to 0.001). Conclusions: These findings showed large differences between leptin concentrations in normal and obese subjects; a progressive increase in leptin concentration with increasing body mass index. These results strongly support an important role for leptin in human metabolism and obesity. Leptin may simply reflect the size of adipose. tissue stores.

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Documento generato il 07/07/20 alle ore 15:44:13