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Titolo:
Pharmacology of sensory gating in the ascending auditory system of the pigeon (Columba livia)
Autore:
Schall, U; Keysers, C; Kast, B;
Indirizzi:
Univ Newcastle, Fac Med & Hlth Sci, Discipline Psychiat, Callaghan, NSW 2308, Australia Univ Newcastle Callaghan NSW Australia 2308 allaghan, NSW 2308, Australia Univ Konstanz, D-7750 Constance, Germany Univ Konstanz Constance GermanyD-7750 nstanz, D-7750 Constance, Germany
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 3, volume: 145, anno: 1999,
pagine: 273 - 282
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS BASALIS PROSENCEPHALI; ACOUSTIC STARTLE RESPONSE; PREPULSE INHIBITION; NEUROTRANSMITTER RECEPTORS; DOPAMINERGIC INNERVATION; PREFRONTAL CORTEX; AVIAN BRAIN; SCHIZOPHRENIA; THALAMUS; RAT;
Keywords:
sensorimotor gating; pepulse inhibition; pigeon; dopamine; glutamate; acetylcholine; nucleus ovoidalis thalami; neostriatum caudale (field L);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Schall, U Univ Newcastle, Fac Med & Hlth Sci, Discipline Psychiat, Callaghan, NSW 2308, Australia Univ Newcastle Callaghan NSW Australia 2308 NSW 2308, Australia
Citazione:
U. Schall et al., "Pharmacology of sensory gating in the ascending auditory system of the pigeon (Columba livia)", PSYCHOPHAR, 145(3), 1999, pp. 273-282

Abstract

Rationale: Whether the underlying neurochemical basis of sensori(motor) gating is exclusively the result of mammalian brain evolution is not known. Objective: The effects of ketamine (KET), benztropine (BTP)? apomorphine (APO), methylphenidatehydrochloride (AMP) and haloperidol (HAL) on sensorimotor gating of the acoustic startle and gating of auditory input into the telelencephalon was assessed in a within-subject design in pigeons (Columba livia) using the prepulse inhibition (PPI) paradigm. Methods: The startle blink reflex was recorded using EMG electrodes which were chronically implantedinto the adjoining Musculus palpepralis superior et inferior, Musculus elevator palpebralis superior, and Musculus nictitantis. Thalamic gating was recorded using electrodes which were chronically implanted into the nucleus ovoidalis thalami and the neostriatum caudale (field L), respectively. Results: KET, APO and AMP disrupted dose-dependently sensorimotor gating. The effect of APO and AMP was blocked by HAL. PPI disruption following BTP did not reach statistical significance. KET disrupted thalamic gating and increased prepulse-induced inhibition in field L. By contrast, AMP increased thalamic and decreased field L inhibition of field potentials when preceded by a pre-stimulus. Both effects were antagonised by HAL thus providing preliminary evidence for a D-2-mediated auditory gating mechanism in the thalamus. However, while the effect of APO at the thalamic level was similar to AMP,prepulse-induced inhibition of field L activity was enhanced. This may be explained by concurrent D-1-mediated telencephalic inhibition. Conclusion: It is concluded that thalamic gating is modulated by a dopaminergic/glutamatergic mechanism. The findings also confirm the notion of an homologous neurochemical basis of sensorimotor gating in mammals and birds.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 21:50:22