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Titolo:
ARTERIAL REACTIVITY IS ENHANCED IN GENETIC MALES TAKING HIGH-DOSE ESTROGENS
Autore:
MCCROHON JA; WALTERS WAW; ROBINSON JTC; MCCREDIE RJ; TURNER L; ADAMS MR; HANDELSMAN DJ; CELERMAJER DS;
Indirizzi:
UNIV SYDNEY,ROYAL PRINCE ALFRED HOSP,DEPT CARDIOL SYDNEY NSW AUSTRALIA UNIV SYDNEY,ROYAL PRINCE ALFRED HOSP,DEPT CARDIOL SYDNEY NSW AUSTRALIA UNIV SYDNEY,ROYAL PRINCE ALFRED HOSP,ANDROL UNIT SYDNEY NSW AUSTRALIA HEART RES INST SYDNEY NSW AUSTRALIA UNIV NEWCASTLE,DISCIPLINE REPROD MED NEWCASTLE NSW 2308 AUSTRALIA
Titolo Testata:
Journal of the American College of Cardiology
fascicolo: 7, volume: 29, anno: 1997,
pagine: 1432 - 1436
SICI:
0735-1097(1997)29:7<1432:ARIEIG>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT DILATION; CORONARY HEART-DISEASE; POSTMENOPAUSAL WOMEN; CIGARETTE-SMOKING; NITRIC-OXIDE; RISK-FACTORS; FOLLOW-UP; ATHEROSCLEROSIS; MORTALITY; ACETYLCHOLINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Mccrohon et al., "ARTERIAL REACTIVITY IS ENHANCED IN GENETIC MALES TAKING HIGH-DOSE ESTROGENS", Journal of the American College of Cardiology, 29(7), 1997, pp. 1432-1436

Abstract

Objectives. We sought to assess whether high dose estrogen treatment is associated with enhanced arterial reactivity in genetic males. Background. Although estrogens have been shown to enhance arterial reactivity in women, and are thereby thought to confer cardiovascular benefit, the vascular effects of long-term estrogen therapy in genetic males is unknown. Methods. We studied the arterial physiology of 30 genetic males-15 male to female transsexuals receiving long-term high dose estrogen therapy and 15 healthy male control subjects matched for age, smoking history and vessel size. Using external vascular ultrasound, brachial artery diameter was measured at rest, after how increase (causing endothelium-dependent dilation [EDD]) and after nitroglycerin (GTN),an endothelium-independent dilator. Blood pressure, cholesterol and testosterone levels were also measured in each subject. Results. Total testosterone and free testosterone index levels were lower in the transsexuals compared with the control subjects (p < 0.001). In contrast, EDD was significantly higher in the transsexuals than in the control males (mean [+/- SD] 7.1 +/- 3.1% vs. 3.2 +/- 2.8%, p = 0.001), as was the GTN response (21.2 +/- 6.7% vs. 14.6 +/- 3.3%, p = 0.002). Total and high density lipoprotein cholesterol, blood pressure levels and baseline vessel size were similar in the two groups. On multivariate analysis, enhanced EDD was associated independently with estrogen therapy (p = 0.02) and with low total cholesterol (p = 0.04). An enhanced GTN response was also significantly associated with estrogen therapy (p = 0.03). Conclusions. Long-term treatment with high dose estrogens is associated with enhanced arterial reactivity in genetic males, which maybe due to the effects of estrogen excess or androgen deprivation, or both. (C) 1997 by the American College of Cardiology.

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Documento generato il 01/04/20 alle ore 00:29:41