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Titolo:
Eukaryotic aldehyde dehydrogenase (ALDH) genes: human polymorphisms, and recommended nomenclature based on divergent evolution and chromosomal mapping
Autore:
Vasiliou, V; Bairoch, A; Tipton, KF; Nebert, DW;
Indirizzi:
Univ Cincinnati, Med Ctr, Ctr Environm Genet, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 m Genet, Cincinnati, OH 45267 USA Univ Cincinnati, Med Ctr, Dept Environm Hlth, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 nm Hlth, Cincinnati, OH 45267 USA Univ Colorado, Hlth Sci Ctr, Sch Pharm, Dept Pharmaceut Sci, Denver, CO USA Univ Colorado Denver CO USA h Pharm, Dept Pharmaceut Sci, Denver, CO USA Univ Geneva, Med Ctr, Dept Biochim Med, Geneva, Switzerland Univ Geneva Geneva Switzerland r, Dept Biochim Med, Geneva, Switzerland Univ Dublin Trinity Coll, Dept Biochem, Dublin 2, Ireland Univ Dublin Trinity Coll Dublin Ireland 2 ept Biochem, Dublin 2, Ireland
Titolo Testata:
PHARMACOGENETICS
fascicolo: 4, volume: 9, anno: 1999,
pagine: 421 - 434
SICI:
0960-314X(199908)9:4<421:EAD(GH>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SJOGREN-LARSSON SYNDROME; GAMMA-AMINOBUTYRALDEHYDE; CYTOPLASMIC ISOENZYME; CDNA SEQUENCE; HUMAN-LIVER; SUPERFAMILY; MUTATIONS; UPDATE; MOUSE; ASSIGNMENT;
Keywords:
Human Gene Nomenclature Committee; Mouse Gene Nomenclature Committee; Human Genome Project; aldehyde dehydrogenase gene superfamily; divergent evolution; consensus signature sequence;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Nebert, DW Univ Cincinnati, Med Ctr, Ctr Environm Genet, POB 670056, Cincinnati, OH 45267 USA Univ Cincinnati POB 670056 Cincinnati OH USA 45267 OH 45267 USA
Citazione:
V. Vasiliou et al., "Eukaryotic aldehyde dehydrogenase (ALDH) genes: human polymorphisms, and recommended nomenclature based on divergent evolution and chromosomal mapping", PHARMACOGEN, 9(4), 1999, pp. 421-434

Abstract

As currently being performed with an increasing number of superfamilies, astandardized gene nomenclature system is proposed here, based on divergentevolution, using multiple alignment analysis of all 86 eukaryotic aldehydedehydrogenase (ALDH) amino-acid sequences known at this time. The ALDHs represent a superfamily of NAD(P)(+)-dependent enzymes having similar primarystructures that oxidize a wide spectrum of endogenous and exogenous aliphatic and aromatic aldehydes, To date, a total of 54 animal, 15 plant, 14 yeast, and three fungal ALDH genes or cDNAs hare been sequenced, These ALDHs can be divided into a total of 18 families (comprising 37 subfamilies), and all nonhuman ALDH genes are named here after the established human ALDH genes, when possible. An ALDH protein from one gene family is defined as having approximately less than or equal to 40% amino-acid identity to that from another family. Two members of the same subfamily exhibit approximately greater than or equal to 60% amino-acid identity and are expected to be located at the same subchromosomal site, For naming each gene, it is proposed that the root symbol 'ALDH' denoting 'aldehyde dehydrogenase' be followed by an Arabic number representing the family and, when needed, a letter designating the subfamily and an Arabic number denoting the individual gene within the subfamily; all letters are capitalized in all mammals except mouse and fruit fly, e.g. 'human ALDH3A1 (mouse, Drosophila Aldh3a1),' It is suggested that the Human Gene Nomenclature Guidelines (http://www.gene.ucl.ac.uk/nomenclature/guidelines.html) be used for all species other than mouse and Drosophila. Following these guidelines, the gene is italicized, whereas the corresponding cDNA, mRNA, protein or enzyme activity is written with upper-case letters and without italics, e.g. 'human, mouse or Drosophila ALDH3A1 cDNA, mRNA, or activity'. If an orthologous gene between species cannot be identified with certainty, sequential naming of these genes will be carried out in chronological order as they are reported to us. In addition, 20 human ALDH variant alleles that have been reported to date are listed herein and are recommended to be given numbers (or a number plus a capital letter) following an asterisk (e.g. 'ALDH3A2*2, ALDH2*4C'). It is anticipated that this eukaryotic ALDH gene nomenclature system will be extended to include bacterial genes within the next 2 years and that this nomenclature system will require updating on a regular basis; an ALDH Web site has been established for this purpose (http://www.uchsc.edu/sp./sp./alcdbase/aldhcov.html) andwill serve as a medium for interaction amongst colleagues in this held. Pharmacogenetics 9:421-434 (C) 1999 Lippincott Williams & Wilkins.

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Documento generato il 30/11/20 alle ore 10:20:54