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Titolo:
Relationship between a genetic predisposition to hypertension, blood pressure levels and pain sensitivity
Autore:
Guasti, L; Gaudio, G; Zanotta, D; Grimoldi, P; Petrozzino, MR; Tanzi, F; Bertolini, A; Grandi, AM; Venco, A;
Indirizzi:
Univ Insubria, Fac Med, Dept Clin & Biol Sci, Chair Internal Med, Varese, Italy Univ Insubria Varese Italy Biol Sci, Chair Internal Med, Varese, Italy
Titolo Testata:
PAIN
fascicolo: 3, volume: 82, anno: 1999,
pagine: 311 - 317
SICI:
0304-3959(199909)82:3<311:RBAGPT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
BARORECEPTOR STIMULATION; INDUCED ANALGESIA; PULP STIMULATION; ANGINA-PECTORIS; FAMILY HISTORY; MENTAL STRESS; PERCEPTION; HUMANS; RATS; NORMOTENSIVES;
Keywords:
blood pressure; hypertension, essential; parental history of hypertension; pain threshold; analgesia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Guasti, L Univ Insubria, Fac Med, Dept Clin & Biol Sci, Chair Internal Med, Viale Borri 57, Varese, Italy Univ Insubria Viale Borri 57 Varese Italyri 57, Varese, Italy
Citazione:
L. Guasti et al., "Relationship between a genetic predisposition to hypertension, blood pressure levels and pain sensitivity", PAIN, 82(3), 1999, pp. 311-317

Abstract

Introduction: The aim of this study was to determine whether the degree ofblood pressure elevation and/or a genetic predisposition to hypertension have a major role in determining a reduced pain perception in hypertensives. The reasons underlying the relationship between blood pressure elevation and pain perception mechanisms are not completely understood. Methods: One hundred and four untreated hypertensive patients (65 subjects with and 39 without a positive parental history of hypertension) together with a control group of 42 subjects (20 normotensive offspring of normotensive parents, and 22 normotensive offspring of hypertensive parents) were submitted to standard blood pressure evaluation, 24-h blood pressure monitoring and dental pain perception evaluation. Results: Both pain threshold and tolerance were found to be higher in hypertensive than normotensive subjects (P < 0.0001 and P < 0.015, respectively). Positive significant correlations were found between both 24-h systolic and diastolic pressure and the pain perception variables. When a 2 x 2 ANOVA test was performed, factoring for the effects of both blood pressure status and family history of hypertension on pain sensitivity, a significant effect was revealed only for blood pressure status. Moreover, after controlling for blood pressure by a covariate analysis, nosignificant difference was found between the subjects with or without hypertensive parents as regards pain perception variables. Conclusions: Pain sensitivity is correlated to blood pressure levels whereas the parental history of hypertension per se does not affect the pain perception pattern. Thus, the degree of blood pressure elevation, more than a genetic predisposition to hypertension may influence the mechanisms leading to hypalgesia in hypertension. (C) 1999 International Association for the Study of Pain. Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 21:33:36