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Titolo:
Expression of inducible nitric oxide synthase immunoreactivity in rat brain following chronic hypoxia: effect of aminoguanidine
Autore:
Niwa, K; Takizawa, S; Kawaguchi, C; Kamiya, U; Kuwahira, I; Shinohara, Y;
Indirizzi:
Tokai Univ, Sch Med, Dept Neurol, Isehara, Kanagawa 2591193, Japan Tokai Univ Isehara Kanagawa Japan 2591193 sehara, Kanagawa 2591193, Japan Tokai Univ, Sch Med, Dept Respirol, Isehara, Kanagawa 2591193, Japan TokaiUniv Isehara Kanagawa Japan 2591193 sehara, Kanagawa 2591193, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 271, anno: 1999,
pagine: 109 - 112
SICI:
0304-3940(19990820)271:2<109:EOINOS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL ANGIOGENESIS;
Keywords:
chronic normobaric hypoxia; inducible nitric oxide synthase; angiogenesis; brain ischemia; aminoguanidine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Shinohara, Y Tokai Univ, Sch Med, Dept Neurol, Isehara, Kanagawa 2591193, Japan Tokai Univ Isehara Kanagawa Japan 2591193 awa 2591193, Japan
Citazione:
K. Niwa et al., "Expression of inducible nitric oxide synthase immunoreactivity in rat brain following chronic hypoxia: effect of aminoguanidine", NEUROSCI L, 271(2), 1999, pp. 109-112

Abstract

To clarify the role of inducible nitric oxide synthase (iNOS) in the histopathological changes that occur in the brain after exposure of rats to normobaric hypoxia (10% O-2 in N-2) for 2 weeks, we examined the localization of iNOS and the effect of aminoguanidine, a relatively selective iNOS inhibitor, on the histological outcome. Animals were divided into a hypoxia group, an aminoguanidine-treated hypoxia group and a normoxic control group. Thehypoxia group showed severe ischemic changes and prominent angiogenesis inthe CA1 hippocampus and cerebral cortex. Aminoguanidine significantly reduced the ischemic change and angiogenesis in these regions, and also reducediNOS-immunoreactive cells compared to the hypoxia group. These findings suggest that iNOS activity could play a role in the neuropathological alterations induced by chronic hypoxia. (C) 1999 Elsevier Science Ireland Ltd. Allrights reserved.

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Documento generato il 08/04/20 alle ore 12:09:12