Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PET imaging of dopamine D-2 receptors with [F-18]fluoroclebopride in monkeys: Effects of isoflurane- and ketamine-induced anesthesia
Autore:
Nader, MA; Grant, KA; Gage, HD; Ehrenkaufer, RL; Kaplan, JR; Mach, RH;
Indirizzi:
Wake Forest Univ, Sch Med, Dept Physiol & Pharmacol, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA Wake Forest Univ, Sch Med, Dept Pathol, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA Wake Forest Univ, Sch Med, Dept Radiol, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 4, volume: 21, anno: 1999,
pagine: 589 - 596
SICI:
0893-133X(199910)21:4<589:PIODDR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; C-11 N-METHYLSPIPERONE; IN-VIVO; PREFRONTAL CORTEX; BRAIN-REGIONS; RHESUS-MONKEY; BINDING; RELEASE; RACLOPRIDE; SCHIZOPHRENIA;
Keywords:
dopamine D-2 receptors; positron emission tomography; fluoroclebopride; isoflurane; ketamine; monkey;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Nader, MA Wake Forest Univ, Sch Med, Dept Physiol & Pharmacol, Med Ctr Blvd, WinstonSalem, NC 27157 USA Wake Forest Univ Med Ctr Blvd Winston Salem NC USA 27157 157 USA
Citazione:
M.A. Nader et al., "PET imaging of dopamine D-2 receptors with [F-18]fluoroclebopride in monkeys: Effects of isoflurane- and ketamine-induced anesthesia", NEUROPSYCH, 21(4), 1999, pp. 589-596

Abstract

The purpose of the present study was to determine whether positron emission tomography (PET) studies in monkeys with the dopamine (DA) D-2 receptor ligand [F-18]fluroclebopride (FCP) would be significantly influenced by anesthetic induction with isoflurane (similar to 5.0%) compared to induction with 10 mg/kg ketamine. Five experimentally-naive adult male cynomolgus monkeys (Macaca fascicularis) were trained to sit calmly in a primate restraint chair. Before thefirst PET scan, each monkey was anesthetized, by mask, with isoflurane. After complete sedation, the monkey was intubated and anesthesia was maintained throughout the PET study by isoflurane (similar to 1.5%). At least 1 month later, a second PET study was conducted in which anesthesia was induced with ketamine and maintained by isoflurane (similar to 1.5%). Irrespective of induction anesthetic, there teas a high uptake of[F-18]FCP and a linear rate of washout from the basal ganglia for all monkeys. There were also MO differences in time to peak uptake (similar to 25 min), in clearance half-life (t(1/2)= 140-164 min) or in D-2 binding (distribution volume ratios of 2.48 vs. 2.50). These results indicate that induction anesthetic did not differentially affect D-2 binding of [F-18]FCP in monkeys. Furthermore, the low variability between studies indicates that [F-18]FCP is an excellent ligand for longitudinal studies of D-2, receptors in monhuman primates. (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:05:49