Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DRUG-TREATMENT OF SCHIZOPHRENIA IN THE 1990S - ACHIEVEMENTS AND FUTURE POSSIBILITIES IN OPTIMIZING OUTCOMES
Autore:
FLEISCHHACKER WW; HUMMER M;
Indirizzi:
INNSBRUCK UNIV CLIN,DEPT BIOL PSYCHIAT,ANICHSTR 35 A-6020 INNSBRUCK AUSTRIA
Titolo Testata:
Drugs
fascicolo: 6, volume: 53, anno: 1997,
pagine: 915 - 929
SICI:
0012-6667(1997)53:6<915:DOSIT1>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM TREATMENT; DOUBLE-BLIND TRIAL; TREATMENT-RESISTANT SCHIZOPHRENIA; PLASMA CLOZAPINE CONCENTRATIONS; CLINICAL-RESPONSE; NEGATIVE SYMPTOMS; PHARMACOLOGICAL TREATMENT; ANTIPSYCHOTIC-DRUGS; TARDIVE-DYSKINESIA; EXTRAPYRAMIDAL SYMPTOMS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
146
Recensione:
Indirizzi per estratti:
Citazione:
W.W. Fleischhacker e M. Hummer, "DRUG-TREATMENT OF SCHIZOPHRENIA IN THE 1990S - ACHIEVEMENTS AND FUTURE POSSIBILITIES IN OPTIMIZING OUTCOMES", Drugs, 53(6), 1997, pp. 915-929

Abstract

The current state of the art of the pharmacological treatment of schizophrenia, and a review of the latest findings in antipsychotic drug development are presented. A first step in optimising treatment is an increase in the awareness and implementation of existing treatment standards. The introduction of clozapine challenges the view that all antipsychotics are of similar efficacy; the drug has an established superiority over some of the traditional antipsychotics in treatment-resistant patients. Newer agents such as zotepine, risperidone, quetiapine, olanzapine and sertindole, which have a lower risk of producing extrapyramidal motor symptoms, have been developed in the wake of clozapine. While it is still common to switch nonresponding patients to an antipsychotic of a different chemical class, clozapine treatment remains theonly strategy based on sound scientific evidence in these patients, although the novel antipsychotics give rise to hope. Alternatively, combination treatment with benzodiazepines, lithium or an anticonvulsant has been employed. If treatment with a depot antipsychotic is planned,it is advisable to start a patient on the oral form of the same drug in order to obtain dose requirements and tolerability information of the drug in that patient. Long term maintenance therapy is crucial and continuous monitoring for the development of adverse effects essential.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:39:18