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Titolo:
Tracing autonomic innervation of the rat pineal gland using viral transneuronal tracing
Autore:
Larsen, PJ;
Indirizzi:
Univ Copenhagen, Panum Inst, Dept Anat, Sect B, DK-2200 Copenhagen N, Denmark Univ Copenhagen Copenhagen Denmark N ct B, DK-2200 Copenhagen N, Denmark
Titolo Testata:
MICROSCOPY RESEARCH AND TECHNIQUE
fascicolo: 4-5, volume: 46, anno: 1999,
pagine: 296 - 304
SICI:
1059-910X(19990815)46:4-5<296:TAIOTR>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; PHASEOLUS-VULGARIS-LEUKOAGGLUTININ; IMMUNOREACTIVE NERVE-FIBERS; SUPERIOR CERVICAL-GANGLION; FEMALE ALBINO-RAT; SUPRACHIASMATIC NUCLEUS; PSEUDORABIES VIRUS; SPINAL-CORD; EFFERENT PROJECTIONS; RETINOHYPOTHALAMIC TRACT;
Keywords:
pseudorabies virus; suprachiasmatic nucleus; hypo thalamic paraventricular nucleus; sympathetic innervation; parasympathetic innervation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Larsen, PJ Univ Copenhagen, Panum Inst, Dept Anat, Sect B, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark Univ Copenhagen Blegdamsvej 3 Copenhagen Denmark N N, Denmark
Citazione:
P.J. Larsen, "Tracing autonomic innervation of the rat pineal gland using viral transneuronal tracing", MICROSC RES, 46(4-5), 1999, pp. 296-304

Abstract

We have used the neurotropic Bartha strain of pseudorabies virus (PRV) to characterise the pathway linking the endogenous circadian pacemaker of the suprachiasmatic nucleus (SCN) to the pineal gland. This low virulent strainof virus replicates within synaptically linked neurones and is ideally suited to visualise the multisynaptic pathways through which the SCN modulatesthe activity of the rat pineal gland. Using specific antibodies against PRV, we could follow the immunohistochemical pattern of the spatiotemporal passage of virus through the sympathetic trunk and the neuraxis. The time course of virus infection indicated that the most prominent pathway from the SCN to the pineal gland is via a final sympathetic innervation from the superior cervical ganglion (SCG). The pathway arises in the! dorsomedial portion of the SCN from where neurones project to the dorsal parvicellular subdivision of the hypothalamic paraventricular nucleus (PVN) to form synaptic contact with neurones descending to the intermediolateral nucleus (IML) of the upper thoracic spinal cord. The neurones of the IML constitute the presynaptic sympathetic input synaptically connected to postsynaptic sympathetic neurones in the SCG which constitute the final input to the pineal gland. Removal of the superior cervical ganglion (SCGX) prior to viral infection completely abolished infection of neurones in this circuit. However, an additional parasympathetic projection from the superior salivatory nucleus via the sphenopalatine ganglion to the pineal gland was observed in SCGX animals. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:32:56