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Titolo:
Overexpression of the m4 and m alpha genes of the E(spl)-Complex antagonizes Notch mediated lateral inhibition
Autore:
Apidianakis, Y; Nagel, AC; Chalkiadaki, A; Preiss, A; Delidakis, C;
Indirizzi:
Univ Crete, Inst Mol Biol & Biotechnol, FORTH, GR-71110 Heraklion, Greece Univ Crete Heraklion Greece GR-71110 , FORTH, GR-71110 Heraklion, Greece Univ Crete, Dept Biol, GR-71110 Heraklion, Greece Univ Crete Heraklion Greece GR-71110 pt Biol, GR-71110 Heraklion, Greece Univ Hohenheim, Dept Genet 240, D-70593 Stuttgart, Germany Univ HohenheimStuttgart Germany D-70593 240, D-70593 Stuttgart, Germany
Titolo Testata:
MECHANISMS OF DEVELOPMENT
fascicolo: 1-2, volume: 86, anno: 1999,
pagine: 39 - 50
SICI:
0925-4773(199908)86:1-2<39:OOTMAM>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPLIT COMPLEX GENES; SENSORY ORGAN DEVELOPMENT; LOOP-HELIX PROTEINS; CELL FATE DECISIONS; DROSOPHILA-MELANOGASTER; EARLY NEUROGENESIS; NEURAL DEVELOPMENT; IMAGINAL DISC; ENHANCER; EXPRESSION;
Keywords:
E(spl) locus; E(spl)m4; E(spl)m alpha; sensory organ precursor specification; lateral inhibition; intercellular signalling; notch signalling; Drosophila;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Delidakis, C Univ Crete, Inst Mol Biol & Biotechnol, FORTH, Box 1527, GR-71110 Heraklion, Greece Univ Crete Box 1527 Heraklion Greece GR-71110 aklion, Greece
Citazione:
Y. Apidianakis et al., "Overexpression of the m4 and m alpha genes of the E(spl)-Complex antagonizes Notch mediated lateral inhibition", MECH DEVEL, 86(1-2), 1999, pp. 39-50

Abstract

Intercellular signalling mediated by Notch proteins is crucial to many cell fate decisions in metazoans. Its profound effects on cell fate and proliferation require that a complex set of responses involving positive and negative signal transducers be orchestrated around each instance of signalling. In Drosophila the basic-helix-loop-helix (bHLH) repressor encoding genes of the E(spl) locus are induced by Notch signalling and mediate some of its effects, such as suppression of neural fate. Here we report on a novel family of Notch responsive genes, whose products appear to act as antagonists of the Notch signal in the process of adult sensory organ precursor singularization. They, too, reside in the E(spl) locus and comprise transcription units E(spl) m4 and E(spl) ma. Overexpression of these genes causes downregulation of E(spl) bHLH expression accompanied by cell autonomous overcommitment of sensory organ precursors and tufting of bristles. Interestingly, negative regulation of the Notch pathway by overexpression of E(spl) m4 and m alpha is specific to the process of sensory organ precursor singularizationand does not impinge on other instances of Notch signalling. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 06:04:08