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Titolo:
Perfusion-corrected mapping of cardiac regional blood volume in rats in vivo
Autore:
Kahler, E; Waller, C; Rommel, E; Belle, V; Hiller, KH; Voll, S; Bauer, WR; Haase, A;
Indirizzi:
Univ Wurzburg, Lehrstuhl Biophys, Inst Phys, D-97074 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97074 t Phys, D-97074 Wurzburg, Germany Univ Mannheim, Med Klin, Mannheim, Germany Univ Mannheim Mannheim Germany iv Mannheim, Med Klin, Mannheim, Germany
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 3, volume: 42, anno: 1999,
pagine: 500 - 506
SICI:
0740-3194(199909)42:3<500:PMOCRB>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTRAST AGENTS; SPIN-RELAXATION; SMALL-VESSEL; QUANTIFICATION; INVERSION; CORONARY; MICROCIRCULATION; EXCHANGE; HEART; WATER;
Keywords:
quantitative MRI; RBV; myocardium; T-1 imaging; perfusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Haase, A Univ Wurzburg, Lehrstuhl Biophys, Inst Phys, Hubland, D-97074 Wurzburg, Germany Univ Wurzburg Hubland Wurzburg Germany D-97074 Wurzburg, Germany
Citazione:
E. Kahler et al., "Perfusion-corrected mapping of cardiac regional blood volume in rats in vivo", MAGN RES M, 42(3), 1999, pp. 500-506

Abstract

Measurement of regional blood volume (RBV) in the myocardium in vivo is important for the assessment of tissue viability and function, The method in this work is based on the acquisition of a T-1 map before and after intravascular contrast agent application, It is known that this method is influenced by perfusion that causes an overestimation of REV values, In order to solve this problem, the new method is proposed which acquires T1 maps with slice selective inversion pulses, Due to blood flow nonexcited spins enter the detection slice, which leads to an acceleration of the relaxation time. Amodel that divides tissue into two compartments is adapted to slice selective inversion in order to derive a simple expression for perfusion-corrected REV. The aim of the study is to demonstrate the feasibility and accuracy of this technique for quantification of REV in rat myocardium in vivo, REV maps were obtained for five rats, and the reproducibility was determined byrepeating the experiment several times. A mean REV value of 12.8 +/- 0.7% (v/v) over all animals was obtained in the myocardium. The results were compared with REV maps obtained with perfusion-sensitive REV imaging in the same five rats and with first-pass REV studies, In order to demonstrate the strength of the new method the vasodilator adenosine was administered and alterations in microcirculation were imaged. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 05:33:25