Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
OSTEOPOROTIC VERTEBRAL FRACTURES IN A MAN UNDER HIGH-DOSE INHALED GLUCOCORTICOID THERAPY - A CASE-REPORT WITH A REVIEW OF THE LITERATURE
Autore:
LAROCHE M; PORTEAU L; CARON P; MOULINIER L; DIDIER A; AMIGUES JM; CANTAGREL A; MAZIERES B;
Indirizzi:
CHU RANGUEIL,SERV RHUMATOL,1 AV J POULHES F-31054 TOULOUSE FRANCE RANGUEIL TEACHING HOSP,DEPT RHEUMATOL TOULOUSE FRANCE RANGUEIL TEACHING HOSP,DEPT ENDOCRINOL TOULOUSE FRANCE RANGUEIL TEACHING HOSP,DEPT PNEUMOL TOULOUSE FRANCE
Titolo Testata:
Revue du rhumatisme
fascicolo: 4, volume: 64, anno: 1997,
pagine: 267 - 270
SICI:
1169-8446(1997)64:4<267:OVFIAM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
BECLOMETHASONE DIPROPIONATE; BONE TURNOVER; CORTICOSTEROIDS; ASTHMA; OSTEOCALCIN; BUDESONIDE; METABOLISM; DENSITY;
Keywords:
OSTEOPOROSIS; BECLOMETHASONE; GLUCOCORTICOID; VERTEBRAL FRACTURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
M. Laroche et al., "OSTEOPOROTIC VERTEBRAL FRACTURES IN A MAN UNDER HIGH-DOSE INHALED GLUCOCORTICOID THERAPY - A CASE-REPORT WITH A REVIEW OF THE LITERATURE", Revue du rhumatisme, 64(4), 1997, pp. 267-270

Abstract

A 65-year-old man had surgery in June 1995 for femoral neuralgia. Theplain films of the spine were normal at the time. In September of thesame year, when he was beginning to walk gradually longer distances, he started experiencing back pain. Crush fractures of T8 and L2 were seen on plain films. His pain worsened, and he was admitted in December1995. A third set of plain films disclosed fractures of all the vertebral bodies from T8 through L5, with increased density of the endplates of the same vertebras. Serum and urinary levels of calcium and phosphate were normal. Dual-energy X-ray absorptiometry demonstrated osteoporosis predominating in the trabecular bone. Evidence of increased bone resorption was seen on the histomorphometric study. Large amounts ofdihydroxypyridinoline were found in the urine. Investigations for theclassical causes of osteoporosis in males were unrewarding. Careful questioning revealed that the patient had been taking inhaled beclomethasone for seven years to treat chronic obstructive lung disease. Serumlevels of cortisol and ACTH were low, consistent with a diagnosis of treatment induced hypercorticism. To our knowledge, this is the first reported case of osteoporotic vertebral fractures in a male due to inhaled glucocorticoid therapy. Inhaled glucocorticoids are generally believed to induce only minimal systemic effects. However decreased serumosteocalcin levels and increased urinary excretion of bone resorptionmarkers have been reported in patients under inhaled beclomethasone therapy. Low spinal bone mineral density values correlated with the degree of pituitary-adrenal gland suppression as evaluated using the ACTHtest have also been found in several groups of patients treated with inhaled glucocorticoids.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 14:21:46