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Titolo:
Molecular mechanisms of gonadotropin-releasing hormone receptor gene regulation
Autore:
Norwitz, ER; Jeong, KH; Chin, WW;
Indirizzi:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Obstet & Gynecol,Div Maternal Fetal Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Maternal Fetal Med, Boston, MA 02115 USA Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Div Mol Genet, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Med,Div Mol Genet, Boston, MA 02115 USA
Titolo Testata:
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
fascicolo: 4, volume: 6, anno: 1999,
pagine: 169 - 178
SICI:
1071-5576(199907/08)6:4<169:MMOGHR>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLLICLE-STIMULATING-HORMONE; MESSENGER-RIBONUCLEIC-ACID; ACTIVATING PROTEIN-1-BINDING SITES; TRANSCRIPTION INITIATION SITES; CELL-SPECIFIC EXPRESSION; ORPHAN NUCLEAR RECEPTOR; STEROIDOGENIC FACTOR-I; ALPHA-SUBUNIT GENE; PROTEIN-KINASE-C; LUTEINIZING-HORMONE;
Keywords:
GnRH; GnRH receptor; gene; transcriptional regulation; AP-1; SURG-1;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Norwitz, ER Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Obstet & Gynecol,Div Maternal Fetal Med, 75 Francis St, Boston, MA 02115 USA Harvard Univ 75 Francis St Boston MA USA 02115 n, MA 02115 USA
Citazione:
E.R. Norwitz et al., "Molecular mechanisms of gonadotropin-releasing hormone receptor gene regulation", J SOC GYN I, 6(4), 1999, pp. 169-178

Abstract

GnRH plays a critical role in regulating mammalian reproductive development and function of the anterior pituitary, GnRH binds to the GnRH receptor GnRHR on the cell surface of pituitary, gonadotropes. Here, it activates intracellular si,signal transduction pathways to effect both the synthesis andintermittent release of the gonadotropins LH and FSH. These hormones then enter the systemic circulation to regulate gonadal function, including steroid hormone systemic and,gametogenesis. The response of pituitary gonadotropes to GnRH correlates directly tl,with the cor concentration of GnRHR oil the cell surface, which is Il mediated, at least in part, at the level of gene expression. A number of endocrine, paracrine, and autocrine factors artknown, to regulate GnRHR gene expression. This ni article reviews in detail the role of the GnRHR ill the hypothalmic-pituitary-gonadal axis and the factors mediating expression of this gene. A better understanding of the molecular mechanisms that regulate transcription of the GnRHR gene will further our knowledge about the role of this receptor in mammalian reproductive physiology in health and disease. Copyright (C) 1999 by the Society for Gynecologic Investigation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 07:31:50