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Titolo:
The relationship of mismatch negativity to quantitative EEG and morphological findings in schizophrenia
Autore:
Kirino, E; Inoue, R;
Indirizzi:
Juntendo Univ, Sch Med, Koshigaya, Saitama 3430032, Japan Juntendo Univ Koshigaya Saitama Japan 3430032 aya, Saitama 3430032, Japan Juntendo Inst Mental Hlth, Koshigaya, Saitama 3430032, Japan Juntendo InstMental Hlth Koshigaya Saitama Japan 3430032 3430032, Japan
Titolo Testata:
JOURNAL OF PSYCHIATRIC RESEARCH
fascicolo: 5, volume: 33, anno: 1999,
pagine: 445 - 456
SICI:
0022-3956(199909/10)33:5<445:TROMNT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVENT-RELATED POTENTIALS; COMPUTED-TOMOGRAPHY; AUDITORY STIMULUS; WORKING-MEMORY; TEMPORAL-LOBE; P3 AMPLITUDE; ABNORMALITIES; ERP; HYPOFRONTALITY; GENERATION;
Keywords:
schizophrenia; ERP; MMN; quantitative EEG; CT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Kirino, E Duke Univ, Med Ctr, Brain Imaging & Anal Ctr, Box 3808, Durham, NC 27710 USA Duke Univ Box 3808 Durham NC USA 27710 808, Durham, NC 27710 USA
Citazione:
E. Kirino e R. Inoue, "The relationship of mismatch negativity to quantitative EEG and morphological findings in schizophrenia", J PSYCH RES, 33(5), 1999, pp. 445-456

Abstract

The goal of the present study is to investigate the relationships of mismatch negativity (MMN) to other markers in schizophrenics; Quantitative EEG (QEEG), CT and psychopathological ratings. Thirty unmedicated patients (28.4+/- 9.8 y, 20 M) including twenty neuroleptic-naive cases were divided into two groups before treatment; Group A consisted of ten patients with greater MMN amplitudes, while twenty patients with smaller ones were assigned toGroup B. In QEEG, Group A showed a closer profile to healthy controls, indicating their function is less distorted. Group B showed greater power in slow wave, slow alpha and fast beta bands. Their greater slow wave may be implicated in cognitive impairment reflected by attenuated MMN as well as greater dilation in lateral ventricles and Sylvian fissures on CT. After pharmacological treatment with conventional neuroleptics, Group A's MMN decreased, whereas that of Group B increased. Furthermore, neuroleptics' EEG-effects observed in Group A were close to the reported profiles bf healthy subjects, while those in Group B were distinct from them. Conclusively, MMN mighthave crucial associations to other measures underlying the brain pathologyof schizophrenia. The diagnostic value of MMN as a trait-marker was discussed. (C) 1999 Elsevier Science Ltd. Ail rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 18:16:24