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Titolo:
Plasma choline concentrations in children requiring long-term home parenteral nutrition: A case control study
Autore:
Misra, S; Ahn, C; Ament, ME; Choi, HJ; Jenden, DJ; Roch, M; Buchman, AL;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Div Pediat Gastroenterol & Nutr, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Sch Med, Dept Pharmacol, Los Angeles, CA 90024 USAUniv Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Texas, Hlth Sci Ctr, Dept Med, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 Sci Ctr, Dept Med, Houston, TX 77030 USA Univ Texas, Hlth Sci Ctr, Div Gastroenterol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 Div Gastroenterol, Houston, TX 77030 USA
Titolo Testata:
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
fascicolo: 5, volume: 23, anno: 1999,
pagine: 305 - 308
SICI:
0148-6071(199909/10)23:5<305:PCCICR>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATIC STEATOSIS; ACETYLCHOLINE; METHIONINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Buchman, AL Univ Texas, Hlth Sci Ctr, Div Gastroenterol Hepatol & Nutr, 6431 Fannin,MSB 4-234, Houston, TX 77030 USA Univ Texas 6431 Fannin,MSB 4-234Houston TX USA 77030 7030 USA
Citazione:
S. Misra et al., "Plasma choline concentrations in children requiring long-term home parenteral nutrition: A case control study", J PARENT EN, 23(5), 1999, pp. 305-308

Abstract

Background: Low plasma Gee choline concentration has been associated with elevated serum hepatic aminotransferase concentrations and hepatic steatosis in adults who need home parenteral nutrition (HPN). We sought to determine if plasma free choline is similarly reduced in children who need home total parenteral nutrition (TPN), Methods: We compared the plasma free cholineconcentration in 21 children who required long-term HPN with 31 normal controls. Patients had received HPN for 75 +/- 13 (SD) months (range 3-206 months). All control children ingested a normal, mixed, nonvegetarian diet. Results: The mean plasma free choline concentration in the children receivingHPN was significantly lower than normal children (6.6 +/- 4.3 vs 8.0 +/- 2.3 nmol/mL, p =.002). Plasma free choline concentration was correlated withage (r = -0.43,p =.049). Using multiple linear regression analysis for age, sex, and squared age (considered in order to account for possible nonlinearity between choline and age), HPN children showed a steady and significant decline in plasma free choline concentration with increased age at the rate of 0.03 nmol/mL per month. Plasma lipid bound choline concentration did not vary with age. No relationship was seen between either plasma free and lipid bound choline concentration and amount of daily IV lipid infusion. A significant negative correlation was observed between plasma free choline concentration and aspartate aminotransferase (AST) and alanine aminostransferase (ALT) (r = -0.72, p =.04 and r = -0.80, p =.02, respectively). Conclusion: Our data support the notion that patients who need long-term HPN without significant enteral feeding have a significant risk for the development of choline deficiency with its associated hepatic dysfunction.

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Documento generato il 08/04/20 alle ore 09:43:35