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Titolo:
Detection of hepatitis C virus RNA (HCV RNA) in amniotic fluid: a prospective study
Autore:
Delamare, C; Carbonne, B; Heim, N; Berkane, N; Petit, JC; Uzan, S; Grange, JD;
Indirizzi:
Hop St Antoine, Serv Virol, F-75012 Paris, France Hop St Antoine Paris France F-75012 e, Serv Virol, F-75012 Paris, France Hop St Antoine, Serv Gynecol Obstet, F-75012 Paris, France Hop St AntoineParis France F-75012 ynecol Obstet, F-75012 Paris, France Hop Tenon, Serv Gynecol Obstet, Assistance Publ Hop Paris, F-75970 Paris, France Hop Tenon Paris France F-75970 nce Publ Hop Paris, F-75970 Paris, France Hop Tenon, Serv Hepatogastroenterol, Assistance Publ Hop Paris, F-75970 Paris, France Hop Tenon Paris France F-75970 nce Publ Hop Paris, F-75970 Paris, France
Titolo Testata:
JOURNAL OF HEPATOLOGY
fascicolo: 3, volume: 31, anno: 1999,
pagine: 416 - 420
SICI:
0168-8278(199909)31:3<416:DOHCVR>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MATERNAL CELL CONTAMINATION; TO-INFANT TRANSMISSION; POLYMERASE CHAIN-REACTION; PERINATAL TRANSMISSION; VERTICAL TRANSMISSION; MONONUCLEAR-CELLS; PREGNANT-WOMEN; INFECTION; MOTHER; RISK;
Keywords:
amniotic fluid; HCV RNA; hepatitis C virus; vertical transmission;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Delamare, C Hop St Antoine, Serv Virol, 184 Rue Faubourg St Antoine, F-75012 Paris, France Hop St Antoine 184 Rue Faubourg St Antoine Paris France F-75012
Citazione:
C. Delamare et al., "Detection of hepatitis C virus RNA (HCV RNA) in amniotic fluid: a prospective study", J HEPATOL, 31(3), 1999, pp. 416-420

Abstract

Background/Aims: Mother-to-infant transmission of hepatitis C virus (HCV) has been reported, but the transmission route is unknown, The aim of our study was to detect HCV RNA in amniotic fluid of pregnant women seropositive for HCV. Methods: Twenty-two HCV seropositive women were included in the study (median age: 39 years). An amniocentesis was performed in all patients during the 4th month of pregnancy. Sixteen women also tested positive for HCV RNA in serum. The range of HCV RNA titers was 0.3 to 15.1 x 10(6) Eq/ml (Quantiplex HCV RNA 2.0 Assay Chiron Diagnostics). Of these 16 viremic patients, four had an anterior placenta, ten had a posterior placenta and the position of the placenta,vas not determined in two cases. PCR (Amplicor HCV, Roche Diagnostics) was used to detect HCV RNA in the amniotic fluid. We also studied 11 HCV seronegative women as a control group,Results: In the viremic group (n=16), HCV RNA was detected once in amniotic fluid. The positive specimen was collected from a patient with atl HCV RNA serum value equal to 1.1 x 10(6) Eq/ml. The placenta was in an anterior position. A PCR inhibitor was detected in one case. No HCV RNA tvas detectedin the amniotic fluid of sis seropositive non-viremic patients, nor in thecontrol group. Serum HCV RNA was negative in the ten children tested, The woman whose amniotic fluid contained HCV RNA was the mother of one of them. Conclusions: HCV RNA detection in amniotic fluid is rarely positive. The anterior position of the placenta ill the only positive detection cannot rule out contamination of the amniotic fluid during the transplacental amniocentesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:16:24