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Titolo:
Does the donor-recipient ABO blood group compatibility status predict subsequent lung transplantation outcomes?
Autore:
Yu, NC; Haug, MT; Khan, SU; Goormastic, M; Hague, LK; Mehta, AC; Maurer, JR;
Indirizzi:
Daniel Boone Clin, Harlan, KY 40831 USA Daniel Boone Clin Harlan KY USA 40831 el Boone Clin, Harlan, KY 40831 USA
Titolo Testata:
JOURNAL OF HEART AND LUNG TRANSPLANTATION
fascicolo: 8, volume: 18, anno: 1999,
pagine: 764 - 768
SICI:
1053-2498(199908)18:8<764:DTDABG>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVER-TRANSPLANTATION; HEART;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Yu, NC Daniel Boone Clin, S-137,37 Ball Pk Rd, Harlan, KY 40831 USA DanielBoone Clin S-137,37 Ball Pk Rd Harlan KY USA 40831 40831 USA
Citazione:
N.C. Yu et al., "Does the donor-recipient ABO blood group compatibility status predict subsequent lung transplantation outcomes?", J HEART LUN, 18(8), 1999, pp. 764-768

Abstract

Background: The study was conducted to compare lung transplantation outcomes between ABO-identical (AI) and ABO-compatible (AC) recipients. Methods: Charts of lung allograft recipients transplanted between February, 1990 and October, 1995 were reviewed. Standard triple-drug immunosuppression and general antimicrobial prophylaxis were provided. Surveillance spirometry was administered every three months. Flexible bronchoscopy (FB) with transbronchial biopsies (TBBs) were undertaken for clinical indications. Time to event analysis on acute (AR) and chronic (CR) rejection and actuarialsurvival were determined by Kaplan-Meier analysis. Cumulative curves were compared with a log rank test. Comparisons of age, maximum forced expiratory volume in one second (FEV1) in the single (SLT) and double (DLT) lung recipients, duration of intensive care unit and hospital stay were carried outusing the Wilcoxon Rank Sum test. Gender, race, underlying diagnoses, cytomegalovirus (CMV) status and pulmonary reimplantation response (PRR) were compared by Chi-square or Fisher's exact test where appropriate. Results: Of the 100 lung recipients (age = 42.5 +/- 13.4 years; M:F = 50:50), 64 were AI and 36 AC. Median follow-up was 22 (range = 0-78) months. Outcome did not differ significantly between the 2 groups in terms of intensive care unit and hospital stay, PRR incidence and grade, incidence and frequencies of AR, median time and grade of first AR, maximum FEV, for SLT and DLT recipients, incidence of CR and survival at 12 months. Conclusions: As the donor supply remains limited, this could considerably simplify the logistics of future transplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 18:10:53