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Titolo:
Clonal infection with Actinobacillus actinomycetemcomitans following periodontal therapy
Autore:
Ehmke, B; Schmidt, H; Beikler, T; Kopp, C; Karch, H; Klaiber, B; Flemmig, TF;
Indirizzi:
Univ Wurzburg, Dept Periodontol, D-97070 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97070 dontol, D-97070 Wurzburg, Germany Univ Wurzburg, Clin Operat Dent & Periodontol, D-97070 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97070 dontol, D-97070 Wurzburg, Germany Univ Wurzburg, Inst Infect Control & Microbiol, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 robiol, D-97080 Wurzburg, Germany
Titolo Testata:
JOURNAL OF DENTAL RESEARCH
fascicolo: 9, volume: 78, anno: 1999,
pagine: 1518 - 1524
SICI:
0022-0345(199909)78:9<1518:CIWAAF>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCALIZED JUVENILE PERIODONTITIS; PORPHYROMONAS-GINGIVALIS; BACTEROIDES-INTERMEDIUS; SUBGINGIVAL PLAQUE; TRANSMISSION; SEROTYPES; DISEASE; LEUKOTOXIN; FAMILIES; PROBE;
Keywords:
periodontitis therapy; periodontal bacteria; clonal infection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Flemmig, TF Univ Wurzburg, Dept Periodontol, Pleicherwall 2, D-97070 Wurzburg, Germany Univ Wurzburg Pleicherwall 2 Wurzburg Germany D-97070 Germany
Citazione:
B. Ehmke et al., "Clonal infection with Actinobacillus actinomycetemcomitans following periodontal therapy", J DENT RES, 78(9), 1999, pp. 1518-1524

Abstract

Mechanical debridement results in a shift of the bacterial composition in the periodontal pocket on the species level. It is unknown, however, whether a clonal change within a species could lead to the emergence of strains with different levels of virulence. Therefore, in the present study, the genetic variability of Actinobacillus actinomycetemcomitans was assessed and strains identified which were associated with periodontal disease progression following periodontal therapy, i.e., refractory periodontitis. Twenty adult patients with untreated periodontitis and subgingival colonization of A.actinomycetemcomitans were randomly assigned to receive full-mouth scalingalone or scaling with an adjunctive antimicrobial therapy. Both groups received supportive periodontal therapy at 3, 6, 9, 12, 18, and 24 months. Subgingival plaque samples were taken at every visit; venous blood was obtained at 24 months only. A. actinomycetemcomitans isolates were typed by the RAPD method, and antibody reactivity against outer membrane proteins was assessed by immunoblot analysis. Eleven distinct RAPD patterns were found in 18patients completing the study. All patients harbored only one A. actinomycetemcomitans genotype, and within each patient this genotype persisted throughout the 24-month observation period. No differences in the expression ofantibody reactivity against outer membrane proteins were found between strains isolated at baseline and at 24 months. Three genotypes were associatedwith reduced survival rates of teeth without probing attachment loss of 2 mm or more. The results indicated that (i) most patients harbored only one A. actinomycetemcomitans genotype; (ii) the genotype persisted following therapy; and (iii) only some genotypes were associated with refractory periodontitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 12:51:42