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Titolo:
Excretion of paroxetine into breast milk
Autore:
Ohman, R; Hagg, S; Carleborg, L; Spigset, O;
Indirizzi:
Reg & Univ Hosp, Dept Clin Pharmacol, N-7006 Trondheim, Norway Reg & Univ Hosp Trondheim Norway N-7006 rmacol, N-7006 Trondheim, Norway Ostersund Hosp, Dept Psychiat, Ostersund, Sweden Ostersund Hosp Ostersund Sweden Hosp, Dept Psychiat, Ostersund, Sweden Norrland Univ Hosp, Div Clin Pharmacol, Umea, Sweden Norrland Univ Hosp Umea Sweden v Hosp, Div Clin Pharmacol, Umea, Sweden
Titolo Testata:
JOURNAL OF CLINICAL PSYCHIATRY
fascicolo: 8, volume: 60, anno: 1999,
pagine: 519 - 523
SICI:
0160-6689(199908)60:8<519:EOPIBM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPARTEINE OXIDATION POLYMORPHISM; POSTNATAL DEPRESSION; FLUOXETINE; NORFLUOXETINE; CITALOPRAM; CHILDREN; INFANTS; IMPACT; MOTHER; RISK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Spigset, O Reg & Univ Hosp, Dept Clin Pharmacol, N-7006 Trondheim, Norway Reg & Univ Hosp Trondheim Norway N-7006 006 Trondheim, Norway
Citazione:
R. Ohman et al., "Excretion of paroxetine into breast milk", J CLIN PSY, 60(8), 1999, pp. 519-523

Abstract

Background: The study was carried out to quantify the excretion of the selective serotonin reuptake inhibitor paroxetine in breast milk. Method: In 6 lactating women, the concentrations of paroxetine in breast milk and serum were studied at the times for assumed minimum (24 hours afterdose intake) and maximum (4-7 hours after dose intake) drug levels in milk. Moreover, a seventh subject was studied with frequent and regular sampling throughout a dose interval of 24 hours at 2 different dose levels. Results: The mean milk/serum concentration ratios in the first 6 subjects ranged from 0.39 to 1.11 (overall mean +/- SD = 0.69 +/- 0.29), and the mean estimated dose to the infants ranged from 0.7% to 2.9% (overall mean +/- SD = 1.4% +/- 0.79%) of the weight-adjusted maternal dose. Based on area-under-the-curve data from the seventh subject, the milk/serum concentration ratio was 0.69 at a dose of 20 mg/day and 0.72 at a dose of 40 mg/day; the estimated relative doses to the infant were 1.0% and 2.0%, respectively. Themean increase in milk paroxetine concentrations from assumed minimum to assumed maximum was 61% (range, 48-172%; p < .01). The mean paroxetine concentration in hindmilk was 78% higher than in foremilk (range, 16%-169%; p < .01), an increase that was parallel to the increase in milk triglyceride levels (r = 0.83, p = .005). No adverse drug reactions or unusual behaviors were reported in the infants. Conclusion: The study indicates that the relative dose to a suckling infant for paroxetine is lower than that reported for fluoxetine and citalopram and higher than that reported for sertraline and fluvoxamine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:10:39