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Titolo:
The casein kinase I alpha isoform is both physically positioned and functionally competent to regulate multiple events of mRNA metabolism
Autore:
Gross, SD; Loijens, JC; Anderson, RA;
Indirizzi:
Univ Wisconsin, Sch Med, Dept Pharmacol, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 Dept Pharmacol, Madison, WI 53706 USA Univ Wisconsin, Cell & Mol Biol Program, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 l Biol Program, Madison, WI 53706 USA
Titolo Testata:
JOURNAL OF CELL SCIENCE
fascicolo: 16, volume: 112, anno: 1999,
pagine: 2647 - 2656
SICI:
0021-9533(199908)112:16<2647:TCKIAI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
RNA-POLYMERASE-II; PRE-MESSENGER-RNA; RETINOBLASTOMA GENE-PRODUCT; DISCRETE NUCLEAR DOMAINS; CDK-ACTIVATING KINASE; SPLICING FACTORS; CELL-CYCLE; MAMMALIAN-CELLS; PROTEIN-KINASES; TRANSCRIPTION FACTOR;
Keywords:
casein kinase; nuclear speckle; mRNA processing; SR protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Anderson, RA Univ Wisconsin, Sch Med, Dept Pharmacol, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 l, Madison, WI 53706 USA
Citazione:
S.D. Gross et al., "The casein kinase I alpha isoform is both physically positioned and functionally competent to regulate multiple events of mRNA metabolism", J CELL SCI, 112(16), 1999, pp. 2647-2656

Abstract

Casein kinase I is a highly conserved family of serine/threonine protein kinases present in every organism tested from yeast to humans. To date, little is known about the function of the higher eukaryotic isoforms in this family, The CKI isoforms in Saccharomyces cerevisiae, however, have been genetically linked to the regulation of DNA repair, cell cycle progression and cytokinesis. It has also been established that the nuclear localization of two of these isoforms is essential for their function. The work presented here demonstrates that the higher eukaryotic CKI alpha isoform is also present within nuclei of certain established cell lines and associated with discrete nuclear structures. The nature of its nuclear localization was characterized. In this regard, CKI alpha was shown to colocalize with factors involved in pre-mRNA splicing at nuclear speckles and that its association withthese structures exhibited several biochemical properties in common with known splicing factors. The kinase was also shown to be associated with a complex that contained certain splicing factors. Finally, in vitro, CKI alphawas shown to be capable of phosp,horylating particular splicing factors within a region rich in serine/arginine dipeptide repeat motifs suggesting that it has both the opportunity and the capacity to regulate one or more steps of mRNA metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:22:18