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Titolo:
Anti-tuberculosis drug resistance surveillance in Uganda 1996-1997
Autore:
Bretzel, G; Aziz, M; Wendl-Richter, U; Adatu, F; Aisu, T; van Wijnen, A; Sticht-Groh, V;
Indirizzi:
Lerman Leprosy Relief Assoc, Armauer Hansen Inst, D-97074 Wurzburg, Germany Lerman Leprosy Relief Assoc Wurzburg Germany D-97074 4 Wurzburg, Germany Lerman Leprosy Relief Assoc, Natl TB & Leprosy Control Programme, Kampala,Uganda Lerman Leprosy Relief Assoc Kampala Uganda ol Programme, Kampala,Uganda
Titolo Testata:
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
fascicolo: 9, volume: 3, anno: 1999,
pagine: 810 - 815
SICI:
1027-3719(199909)3:9<810:ADRSIU>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Keywords:
tuberculosis; drug resistance; Uganda;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Bretzel, G Lerman Leprosy Relief Assoc, Armauer Hansen Inst, Hermann Schell Str 7, D-97074 Wurzburg, Germany Lerman Leprosy Relief Assoc Hermann Schell Str 7 Wurzburg Germany D-97074
Citazione:
G. Bretzel et al., "Anti-tuberculosis drug resistance surveillance in Uganda 1996-1997", INT J TUBE, 3(9), 1999, pp. 810-815

Abstract

SETTING: Drug resistance surveillance conducted by the National Tuberculosis and Leprosy Control Programme (NTLP) Uganda from 1996-1997 in collaboration with the Armauer Hansen Institute/German Leprosy Relief Association (GLRA), Germany, for the WHO/IUATLD Global Project on Anti-Tuberculosis Drug Resistance Surveillance. OBJECTIVE: To determine the prevalence of primary and acquired anti-tuberculosis drug resistance in Uganda. DESIGN: The survey area covered three GLRA-supported operational NTLP zones, corresponding to 50% of the Ugandan population. A representative random sampling of individual patients was chosen as sampling procedure. Altogether 586 smear-positive TB patients (537 new cases and 49 previously treated cases) were included in the survey. RESULTS: For primary resistance the results were as follows: isoniazid (H)6.7%, rifampicin (R) 0.8%, ethambutol (E) 6.1%, streptomycin (S) 13.4%, thioacetazone (T) 3.2%, pyrazinamide (Z) 0%, multidrug resistance (MDR) 0.5%;for acquired resistance they were: H 37.8%, R 4.4%, S 22.2%, E 11.1%, T 20.0%, Z 0%, and MDR 4.4%. CONCLUSION: According to these data the NTLP Uganda has been effective in preventing high levels of primary drug resistance. If it is assumed that the sampling process reflects the distribution of new patients and previouslytreated patients in the study areas, the amount of acquired resistance (any resistance) in the community of smear-positive patients is approximately 5%. To further monitor programme performance the NTLP will embark on a nationwide survey in 1998/ 1999.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 08:04:20