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Titolo:
Induction of germline transcription in the TCR gamma locus by Stat5: Implications for accessibility control by the IL-7 receptor
Autore:
Ye, SK; Maki, K; Kitamura, T; Sunaga, S; Akashi, K; Domen, J; Weissman, IL; Honjo, T; Ikuta, K;
Indirizzi:
Kyoto Univ, Fac Med, Dept Med Chem, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 Med, Dept Med Chem, Kyoto 6068501, Japan Univ Tokyo, Inst Med Sci, Dept Hematopoiet Factors, Tokyo 1080071, Japan Univ Tokyo Tokyo Japan 1080071 Hematopoiet Factors, Tokyo 1080071, Japan Tokyo Univ Hosp, Dept Hematol & Oncol, Tokyo 1138655, Japan Tokyo Univ Hosp Tokyo Japan 1138655 ematol & Oncol, Tokyo 1138655, Japan Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA Stanford UnivStanford CA USA 94305 , Dept Pathol, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Dev Biol, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 Dept Dev Biol, Stanford, CA 94305 USA
Titolo Testata:
IMMUNITY
fascicolo: 2, volume: 11, anno: 1999,
pagine: 213 - 223
SICI:
1074-7613(199908)11:2<213:IOGTIT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL RECEPTOR; V-J RECOMBINATION; INTERLEUKIN-7 RECEPTOR; DEFICIENT MICE; GENE REARRANGEMENT; TARGETED DELETION; ALPHA-CHAIN; BCL-2; EXPRESSION; LYMPHOPOIESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Ikuta, K Kyoto Univ, Fac Med, Dept Med Chem, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 t Med Chem, Kyoto 6068501, Japan
Citazione:
S.K. Ye et al., "Induction of germline transcription in the TCR gamma locus by Stat5: Implications for accessibility control by the IL-7 receptor", IMMUNITY, 11(2), 1999, pp. 213-223

Abstract

IL-7 receptor (IL-7R) plays critical roles in lymphocyte development by promoting survival and proliferation and by inducing V(D)J recombination in TCR and Ig loci. Here, we demonstrate that IL-7R-activated Stat5 binds to consensus motifs in the 5' regions of J gamma segments and induces germline transcripts. We also show that a constitutively active form of Stat5 restores V-J recombination of TCR gamma genes and partially rescues T cell development from IL-7R(-/-) T cell precursors, especially in favor of gamma delta T cells. Therefore, this study reveals a potential role of Stat5 in T cell development and also implies that IL-7R may control the accessibility of the TCR gamma locus through Stat5-induced germline transcription.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:44:27