Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Nitric oxide synthase in identified olivocochlear projection neurons in rat and guinea pig
Autore:
Riemann, R; Reuss, S;
Indirizzi:
Univ Wurzburg, Dept Otorhinolaryngol, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 ryngol, D-97080 Wurzburg, Germany Univ Mainz, Dept Anat, D-55099 Mainz, Germany Univ Mainz Mainz Germany D-55099 ainz, Dept Anat, D-55099 Mainz, Germany
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 135, anno: 1999,
pagine: 181 - 189
SICI:
0378-5955(199909)135:1-2<181:NOSIIO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUDITORY BRAIN-STEM; COCHLEAR BLOOD-FLOW; MICROSCOPIC LOCALIZATION; EFFERENT INNERVATION; VASODILATING AGENTS; NUCLEUS; NITROPRUSSIDE; ISOFORMS; ENZYME; ORGAN;
Keywords:
nitric oxide synthase; fluoro-gold; retrograde tracing; superior olivary complex; cochlea;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Riemann, R Univ Wurzburg, Dept Otorhinolaryngol, Josef Schneider Str 11, D-97080 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 11 Wurzburg Germany D-97080
Citazione:
R. Riemann e S. Reuss, "Nitric oxide synthase in identified olivocochlear projection neurons in rat and guinea pig", HEARING RES, 135(1-2), 1999, pp. 181-189

Abstract

Nitric oxide (NO) is thought to be involved in the effects of amino acids at the level of cochlear hair cell afferents. Recently, the isoform of the NO-producing enzyme, neuronal NO synthase (nNOS), has been demonstrated in neuronal structures of the cochlea in rats and guinea pigs histochemically and immunohistochemically. To investigate the sources of cochlear NO, we injected Fluoro-Gold (FG) into the cochlea of rats and guinea pigs. Upon terminal uptake of the tracer and neuronal transport we observed FG in terminals at the base of inner (IHC) and outer hair cells (OHC) and in neurons of the spiral ganglion. Ganglion cells and terminals at the IHC were clearly nNOS-positive, while terminals at the OHC exhibited nNOS-immunoreactivity to a minor degree. The immunohistochemical investigation of the auditory brainstem showed that about one-fourth of the neurons of the superior olivary complex contained nNOS. The comparison with retrogradely labeled neurons showed that perikarya in the lateral superior olivary nucleus and, in particular, the medial nucleus of the trapezoid body were double-labeled. These results were similar in both, rat and guinea pig. Our data reveal that neurons of the superior olivary complex are likely to be additional sources of neuronal NOS in the cochlea. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 06:29:24