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Titolo:
Effects in vitro of several antioxidants on the natural killer function ofaging mice
Autore:
Ferrandez, MD; Correa, R; Del Rio, M; De la Fuente, M;
Indirizzi:
Univ Complutense Madrid, Fac Biol Sci, Dept Anim Physiol, E-28040 Madrid, Spain Univ Complutense Madrid Madrid Spain E-28040 siol, E-28040 Madrid, Spain
Titolo Testata:
EXPERIMENTAL GERONTOLOGY
fascicolo: 5, volume: 34, anno: 1999,
pagine: 675 - 685
SICI:
0531-5565(199908)34:5<675:EIVOSA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT CELLULAR CYTOTOXICITY; NEUTROPHIL FUNCTION; MEDIATED-IMMUNITY; T-LYMPHOCYTES; AGED MICE; CELLS; NK; ENHANCEMENT; IL-2; IMMUNOSENESCENCE;
Keywords:
NK cell activity; thioproline; N-acetylcysteine; ascorbic acid; alpha-tocopherol; lymphocytes; macrophages;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: De la Fuente, M Univ Complutense Madrid, Fac Biol Sci, Dept Anim Physiol, E-28040 Madrid, Spain Univ Complutense Madrid Madrid Spain E-28040 drid, Spain
Citazione:
M.D. Ferrandez et al., "Effects in vitro of several antioxidants on the natural killer function ofaging mice", EXP GERONT, 34(5), 1999, pp. 675-685

Abstract

The aim of the present work is to study the change with aging in the effect in vitro of several antioxidants: thiazolidine-4-carboxylic acid or thioproline, N-acetylcysteine (NAC), ascorbic acid (AA), and alpha-tocopherol (vitamin E, VE) on the natural killer (NK) activity in mononuclear cells fromaxillary nodes, spleen, thymus and peritoneal leukocytes from BALB/c male mice. Young (8 +/- 2 weeks), adult (24 +/- 2 weeks), mature (48 +/- 2 weeks), and old (72 +/- 2 weeks) animals were studied. A nonradioactive cytotoxic assay with cells from the murine lymphoma YAC-1 as target cells and a relation effector cells/target cells of 10/1 were used. The concentrations of the different antioxidants were: 1 mM for thioproline and N-acetylcysteine and 5 mu M for ascorbic acid and alpha-tocopherol, which induced a maximum effect in our previous dose-response experiments. The results show that, ingeneral, the above antioxidants cause an enhancement of the NK activity atall ages studied, this stimulation being higher with thioproline and N-acetylcysteine than with ascorbic: acid and alpha-tocopherol. The effects weresimilar for the three lymphoid organs and the peritoneum. This stimulationof the NK activity by antioxidants is an important favorable response, especially in old mice, in which age results in a decrease in NK function and,therefore, in a higher incidence of neoplasia. (C) 1999 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 13:52:55