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Titolo:
An independent association between obstructive sleep apnoea and coronary artery disease
Autore:
Peker, Y; Kraiczi, H; Hedner, J; Loth, S; Johansson, A; Bende, M;
Indirizzi:
Sahlgrens Univ Hosp, Dept Pulm Med, SE-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden SE-41345 -41345 Gothenburg, Sweden Sahlgrens Univ Hosp, Dept Clin Pharmacol, SE-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden SE-41345 -41345 Gothenburg, Sweden Cty Hosp Skaraborg, Dept Internal Med, Skovde, Sweden Cty Hosp Skaraborg Skovde Sweden org, Dept Internal Med, Skovde, Sweden Cty Hosp Skaraborg, Dept Otorhinolaryngol, Skovde, Sweden Cty Hosp Skaraborg Skovde Sweden Dept Otorhinolaryngol, Skovde, Sweden
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 1, volume: 14, anno: 1999,
pagine: 179 - 184
SICI:
0903-1936(199907)14:1<179:AIABOS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
APNEA SYNDROME; MORTALITY; PRESSURE; MEN;
Keywords:
coronary artery disease; risk factor; sleep apnoea;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Peker, Y Sahlgrens Univ Hosp, Dept Pulm Med, SE-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden SE-41345 thenburg, Sweden
Citazione:
Y. Peker et al., "An independent association between obstructive sleep apnoea and coronary artery disease", EUR RESP J, 14(1), 1999, pp. 179-184

Abstract

Previous studies of sleep and breathing suggest an independent associationbetween coronary artery disease (CAD) and obstructive sleep apnoea (OSA) in middle-aged males and females. These studies, however, were criticized because they did not properly adjust for all important confounding factors. In order to better control for the impact of these confounders, a case-control study was performed, matching for age, sex and body mass index (BMI), and additionally adjusting for hypertension, hypercholesterolemia, diabetes mellitus and current smoking. A consecutive selection of 62 patients (44 males and 18 females, mean age 69 yrs, range 44-88 yrs) requiring intensive care for angina pectoris or myocardial infarction at the County Hospital of Skaraborg, Skovde, Sweden, aswell as 62 age-, sex- and BMI- matched control subjects without history orsigns of heart disease underwent an overnight sleep/ventilatory monitoringstudy. The time interval between discharge from the intensive care unit and the overnight study ranged between 4 and 21 months. OSA, defined as a Respiratory Disturbance Index (RDI) of greater than or equal to 10.h(-1), was present in 19 CAD patients but only in eight control subjects (p=0.017). Using a univariate logistic regression analysis, current smoking (odds ratio (OR) 8.1, 95% confidence interval (CI) 2.2-29.0), diabetes mellitus (OR 4.2, 95% CI 1.1-16.1) and OSA (OR 3.0, 95% CI 1.2-7.5), but not hypertension (OR 1.5, 95% CI 0.7-3.2) and hypercholesterolaemia (OR1.8, 95% CI 0.7-4.1) were significantly correlated with CAD. In a multiplelogistic regression model, current smoking (OR 9.8, 95% CI 2.6-36.5), diabetes mellitus (OR 4.2, 95% CI 1.1-17.1) and OSA (OR 3.1, 95% CI 1.2-8.3) all remained independently associated with CAD. In summary, these data suggest a high occurrence of obstructive sleep apnoea in middle-aged and elderly patients with coronary artery disease requiring intensive care, which should be taken into account when considering riskfactors for coronary artery disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 20:11:59