Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Modulatory effects of alveolar macrophages on CD4+T-cell IL-5 responses correlate with IL-1 beta, IL-6, and IL-12 production
Autore:
Tang, C; Rolland, JM; Ward, C; Li, X; Bish, R; Thien, F; Walters, EH;
Indirizzi:
Monash Univ, Alfred Hosp, Dept Resp Med, Melbourne, Vic 3181, Australia Monash Univ Melbourne Vic Australia 3181 , Melbourne, Vic 3181, Australia Monash Univ, Alfred Hosp, Dept Allergy & Clin Immunol, Melbourne, Vic 3181, Australia Monash Univ Melbourne Vic Australia 3181 , Melbourne, Vic 3181, Australia Monash Univ, Sch Med, Dept Pathol & Immunol, Melbourne, Vic 3004, Australia Monash Univ Melbourne Vic Australia 3004 , Melbourne, Vic 3004, Australia
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 1, volume: 14, anno: 1999,
pagine: 106 - 112
SICI:
0903-1936(199907)14:1<106:MEOAMO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CD4(+) T-CELLS; CYTOKINE PROFILES; ATOPIC ASTHMATICS; INTRINSIC ASTHMA; MESSENGER-RNA; ANTIGEN; INTERLEUKIN-12; DIFFERENTIATION; EXPRESSION; GENERATION;
Keywords:
asthma; interleukin-1 beta; interleukin-5; interleukin-6; interleukin-12; macrophage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Walters, EH Monash Univ, Alfred Hosp, Dept Resp Med, Melbourne, Vic 3181, Australia Monash Univ Melbourne Vic Australia 3181 Vic 3181, Australia
Citazione:
C. Tang et al., "Modulatory effects of alveolar macrophages on CD4+T-cell IL-5 responses correlate with IL-1 beta, IL-6, and IL-12 production", EUR RESP J, 14(1), 1999, pp. 106-112

Abstract

Increasing evidence suggests that the pattern of T-cell cytokine production can be modulated by antigen presenting cell (APC)-derived factors during the cell interactions. Recently, it has been shown that alveolar macrophages (AMs) from atopic asthmatics (AA) but not atopic nonasthmatics (AN) enhance interleukin (IL)-5 production by CD4+ T-cells. The present study compared AM production of IL-1 beta, IL-6, and IL-12, aswell as their associated functional capacity to influence IL-5 production by allergen-specific CD4+ T-cells in 10 AA, 10 AN, and nine nonatopic control subjects (C). AMs from AA showed a relatively high production of IL-1 beta and UL-6 (p<0.05) and a relatively low secretion of IL-12 compared to C, whereas AMs from AN and C behaved similarly. This study confirmed previous findings that co-culture with AMs augments IL-5 production from allergen-stimulated CD4+ T-cells only in AA and not in nonasthmatics even if they are atopic. On the other hand, stimulation with allergen alone did not enhance IL-5 productionby CD4+ T-cells in either AA nor AN. AM-induced changes in CD4+ T-cell IL-5 production upon allergen stimulation significantly correlated with their ability to produce IL-1 beta (r=0.59, p<0.01), IL-6 (r=0.56, p<0.01), and inversely with IL-12 (r=-64, p=0.002) in all atopic subjects, and even more closely with the ratio of IL-12/IL-1 beta (r=-0.75, p<0.001) and IL-12/IL-6production (r=-0.81, p<0.001) in these subjects. These findings suggest that the role of alveolar macrophages from atopic asthmatics in enhancing interleukin-5 production by allergen-specific CD4+ T-cells is due, at least partly, to their aberrant production of interleukin-1 beta, interleukin-6, and particularly of interleukin-12.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:06:47