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Titolo:
Cognitive functions after pilocarpine-induced status epilepticus: Changes during silent period precede appearance of spontaneous recurrent seizures
Autore:
Hort, J; Brozek, G; Mares, P; Langmeier, M; Komarek, V;
Indirizzi:
Acad Sci Czech Republ, Inst Physiol, CZ-14220 Prague 4, Czech Republic Acad Sci Czech Republ Prague Czech Republic 4 0 Prague 4, Czech Republic Charles Univ, Dept Physiol, Sch Med 2, Prague, Czech Republic Charles Univ Prague Czech Republic l, Sch Med 2, Prague, Czech Republic Charles Univ, Dept Child Neurol, Sch Med 2, Prague, Czech Republic CharlesUniv Prague Czech Republic l, Sch Med 2, Prague, Czech Republic Charles Univ, Dept Physiol, Sch Med 1, Prague, Czech Republic Charles Univ Prague Czech Republic l, Sch Med 1, Prague, Czech Republic
Titolo Testata:
EPILEPSIA
fascicolo: 9, volume: 40, anno: 1999,
pagine: 1177 - 1183
SICI:
0013-9580(199909)40:9<1177:CFAPSE>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
RATS; DAMAGE; PERFORMANCE; MEMORY; AGE; HIPPOCAMPUS; NAVIGATION; DEFICITS; LITHIUM; LESIONS;
Keywords:
status epilepticus; cognitive functions; pilocarpine; ketamine; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Brozek, G Acad Sci Czech Republ, Inst Physiol, Videnska 1083, CZ-14220 Prague 4, Czech Republic Acad Sci Czech Republ Videnska 1083 Prague Czech Republic 4 lic
Citazione:
J. Hort et al., "Cognitive functions after pilocarpine-induced status epilepticus: Changes during silent period precede appearance of spontaneous recurrent seizures", EPILEPSIA, 40(9), 1999, pp. 1177-1183

Abstract

Purpose: To study the possible relation between spontaneous recurrent seizures (SRS) and the derangement of cognitive memory. Methods: Status epilepticus (SE) was induced in adult Long-Evans rats by pilocarpine (320 mg/kg, i.p.) and interrupted after 2 h by clonazepam (CZPs mg/kg, i.p.). In addition to the animals that were given pilocarpine and CZP (group P), two groups received ketamine (100 mg/kg, i.p.): the first group 15 minutes after SE onset (group K15), and the second immediately after the CZP (group K120). Control groups were formed from animals not treated with pilocarpine as well as animals that received pilocarpine but did not develop motor seizures. Spatial cognitive memory was tested in the Morris water maze. Results: Testing was impossible for more than 6 days after SE in group P. Ketamine shortened this period for the two groups that received it. During the silent period, deteriorated cognitive memory progressively improved, but the performance of group P started to worsen before the appearance of SRS. Group K120 only expressed a tendency toward declining performance, whereas group K15 never developed SRS, and the behavior of these animals did not differ from that of the controls after the postseizure period was over. Histologically, massive hippocampal cell loss was seen in group P. Ketamine protected hippocampal cells in a time-dependent manner; group K15 did not exhibit any obvious necrosis in the hippocampus. Conclusions: There is no close relation between cognitive functions and the appearance of SRS, because ketamine, administered 120 min after the beginning of SE, prevented the derangment of cognitive functions but not the appearance of SRSs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:32:14