Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
NK-104, a potent new 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, enhances posttranslational catabolism of apolipoprotein B-100 and inhibits secretion of apolipoprotein B-100 and triacylglycerols from HepG2 cells
Autore:
Yanagita, T; Hara, E; Yotsumoto, H; Rahman, SM; Han, SY; Cha, JY; Yamamoto, K;
Indirizzi:
Saga Univ, Dept Appl Biol Sci, Saga 8408502, Japan Saga Univ Saga Japan 8408502 iv, Dept Appl Biol Sci, Saga 8408502, Japan Saga Med Sch, Dept Internal Med, Saga, Japan Saga Med Sch Saga JapanSaga Med Sch, Dept Internal Med, Saga, Japan
Titolo Testata:
CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
fascicolo: 8, volume: 60, anno: 1999,
pagine: 423 - 434
SICI:
0011-393X(199908)60:8<423:NAPN3C>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRIGLYCERIDE TRANSFER PROTEIN; B-CONTAINING LIPOPROTEIN; LOW-DENSITY-LIPOPROTEIN; CORONARY HEART-DISEASE; CHOLESTERYL ESTER; OLEIC-ACID; A-I; HYPERCHOLESTEROLEMIA; BIOSYNTHESIS; STIMULATION;
Keywords:
HMG-CoA reductase inhibitor; triacylglycerol; cholesteryl ester; apo B secretion; apo B degradation; HepG2 cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Yanagita, T Saga Univ, Dept Appl Biol Sci, Saga 8408502, Japan Saga Univ Saga Japan 8408502 l Biol Sci, Saga 8408502, Japan
Citazione:
T. Yanagita et al., "NK-104, a potent new 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, enhances posttranslational catabolism of apolipoprotein B-100 and inhibits secretion of apolipoprotein B-100 and triacylglycerols from HepG2 cells", CURR THER R, 60(8), 1999, pp. 423-434

Abstract

The effects of NK-104, a new, potent 3-hydroxy-3-methylglutaryl coenzyme Areductase inhibitor, on the secretion and intracellular catabolism of apolipoprotein B-100 (apo) and on lipid metabolism in HepG2 cells were investigated. The cells were treated with NK-104 1 or 10 mu M for 3 or 24 hours in 1% bovine serum albumin-containing medium. To examine intracellular apo B catabolism, the cells were labeled with S-35-methionine for 10 minutes and followed for up to 90 minutes. NK-104 reduced the secretion of apo B and S-35-labeled apo B, The degradation rate of intracellular S-35-labeled apo B was faster in cells treated with NK-104 than in controls, suggesting that apo B stability was decreased by treatment with NK-104, NK-104 reduced significantly the intracellular levels and synthesis of cholesterol and cholesteryl ester in HepG2 cells. The agent reduced the secretion of labeled triacylglycerols without affecting intracellular triacylglycerol synthesis. Results of this study suggest that NK-104 reduced the secretion of apo B by enhancing degradation of the protein, This effect may be mediated through changes in the intracellular metabolism of cholesterol or cholesteryl ester.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:23:34