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Titolo:
Genes without protein products: Is H19 the norm or the exception?
Autore:
Kanduri, C; Pfeifer, S; Li, YM; Ohlsson, R;
Indirizzi:
Uppsala Univ, Dept Anim Dev & Genet, S-75236 Uppsala, Sweden Uppsala UnivUppsala Sweden S-75236 Dev & Genet, S-75236 Uppsala, Sweden Univ Uppsala Hosp, Dept Pediat, S-75185 Uppsala, Sweden Univ Uppsala HospUppsala Sweden S-75185 Pediat, S-75185 Uppsala, Sweden
Titolo Testata:
CURRENT SCIENCE
fascicolo: 4, volume: 77, anno: 1999,
pagine: 539 - 544
SICI:
0011-3891(19990825)77:4<539:GWPPIH>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
BECKWITH-WIEDEMANN-SYNDROME; IMPRINTING CONTROL REGION; IGF2 EXPRESSION; X-CHROMOSOME; SNRPN GENE; CPG ISLAND; RNA; DELETION; TUMOR; INACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Physical, Chemical & Earth Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Ohlsson, R Uppsala Univ, Dept Anim Dev & Genet, Norbyvagen 18A, S-75236 Uppsala, Sweden Uppsala Univ Norbyvagen 18A Uppsala Sweden S-75236 ala, Sweden
Citazione:
C. Kanduri et al., "Genes without protein products: Is H19 the norm or the exception?", CURRENT SCI, 77(4), 1999, pp. 539-544

Abstract

The increasing number of RNA polymease II transcripts without any apparentopen reading frame has increased our awareness that gene functions can be selected for without involving a protein product. By using the H19 gene as a point of reference, we highlight here several common features among non-coding genes, such as their antisense position in subchromosomal expression domains which are often genomically imprinted. We also discuss the need to critically examine the translatability of transcripts which are considered non-coding. Finally, we present a model to explain the origin of non-codinggenes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:32:38