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Titolo:
Aluminum, iron, lead, cadmium, copper, zinc, chromium, magnesium, strontium, and calcium content in bone of end-stage renal failure patients
Autore:
DHaese, PC; Couttenye, MM; Lamberts, LV; Elseviers, MM; Goodman, WG; Schrooten, I; Cabrera, WE; De Broe, ME;
Indirizzi:
Univ Antwerp, Dept Nephrol Hypertens, B-2650 Edegem, Belgium Univ AntwerpEdegem Belgium B-2650 rol Hypertens, B-2650 Edegem, Belgium Univ Calif Los Angeles, Sch Med, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
CLINICAL CHEMISTRY
fascicolo: 9, volume: 45, anno: 1999,
pagine: 1548 - 1556
SICI:
0009-9147(199909)45:9<1548:AILCCZ>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATOMIC-ABSORPTION SPECTROMETRY; TRACE-ELEMENTS; GRAPHITE-FURNACE; HEMODIALYSIS-PATIENTS; ALKALINE-PHOSPHATASE; DIALYSIS PATIENTS; SOFT-TISSUES; SERUM; URINE; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: De Broe, ME Univ Antwerp, Univ Antwerp Hosp, Dept Nephrol Hypertens, Wilrijkstr 10, B-2650 Edegem, Belgium Univ Antwerp Wilrijkstr 10 Edegem BelgiumB-2650 gem, Belgium
Citazione:
P.C. D'Haese et al., "Aluminum, iron, lead, cadmium, copper, zinc, chromium, magnesium, strontium, and calcium content in bone of end-stage renal failure patients", CLIN CHEM, 45(9), 1999, pp. 1548-1556

Abstract

Background: Little is known about trace metal alterations in the bones of dialysis patients or whether particular types of renal osteodystrophy are associated with either increased or decreased skeletal concentrations of trace elements. Because these patients are at risk for alterations of trace elements as well as for morbidity from skeletal disorders, we measured trace elements in bone of patients with end-stage renal disease. Methods: We analyzed bone biopsies of 100 end-stage renal failure patientsenrolled in a hemodialysis program. The trace metal contents of bone biopsies with histological features of either osteomalacia, adynamic bone disease, mixed lesion, normal histology, or hyperparathyroidism were compared with each other and with the trace metal contents of bone of subjects with normal renal function. Trace metals were measured by atomic absorption spectrometry. Results: The concentrations of aluminum, chromium, and cadmium were increased in bone of end-stage renal failure patients. Comparing the trace metal/calcium ratio, significantly higher values were found for the bone chromium/calcium, aluminum/calcium, zinc/calcium, magnesium/calcium, and strontium/calcium ratios. Among types of renal osteodystrophy, increased bone aluminum, lead, and strontium concentrations and strontium/calcium and aluminum/calcium ratios were found in dialysis patients with osteomalacia vs the othertypes of renal osteodystrophy considered as one group. Moreover, the concentrations of several trace elements in bone were significantly correlated with each other. Bone aluminum was correlated with the time on dialysis, whereas bone iron, aluminum, magnesium, and strontium tended to be associated with patient age. Bone trace metal concentrations did not depend on vitaminD intake nor on the patients' gender. Conclusions: The concentration of several trace elements in bone of end-stage renal failure patients is disturbed, and some of the trace metals understudy might share pathways of absorption, distribution, and accumulation. The clinical significance of the increased/ decreased concentrations of several trace elements other than aluminum in bone of dialysis patients deserves further investigation. (C) 1999 American Association for Clinical Chemistry.

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Documento generato il 30/11/20 alle ore 07:16:54