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Titolo:
DIFFERENT EXPRESSION OF HLA-DR AND ICAM-1 IN LIVERS FROM PATIENTS WITH BILIARY ATRESIA AND BALERS DISEASE
Autore:
BROOME U; NEMETH A; HULTCRANTZ R; SCHEYNIUS A;
Indirizzi:
HUDDINGE HOSP,UNIT GASTROENTEROL & HEPATOL,K63 S-14186 STOCKHOLM SWEDEN KAROLINSKA INST,HUDDINGE & KAROLINSKA HOSP,DEPT MED STOCKHOLM SWEDEN KAROLINSKA INST,HUDDINGE & KAROLINSKA HOSP,DEPT PAEDIAT STOCKHOLM SWEDEN KAROLINSKA INST,HUDDINGE & KAROLINSKA HOSP,DEPT CLIN IMMUNOL STOCKHOLM SWEDEN
Titolo Testata:
Journal of hepatology
fascicolo: 4, volume: 26, anno: 1997,
pagine: 857 - 862
SICI:
0168-8278(1997)26:4<857:DEOHAI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY SCLEROSING CHOLANGITIS; KUPFFER CELLS; HEPATOCYTES; REOVIRUS-3; INFECTION; CIRRHOSIS;
Keywords:
ADHESION MOLECULES; CLASS II TRANSPLANTATION ANTIGENS; NEONATAL CHOLESTASIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
U. Broome et al., "DIFFERENT EXPRESSION OF HLA-DR AND ICAM-1 IN LIVERS FROM PATIENTS WITH BILIARY ATRESIA AND BALERS DISEASE", Journal of hepatology, 26(4), 1997, pp. 857-862

Abstract

Background/Aims: Extrahepatic biliary atresia (EHBA) and chronic progressive intra-hepatic cholestasis (Byler's disease) are two distinct disorders of unknown etiology in the neonate, characterized by profoundcholestasis. The aim of the present study was to investigate the inflammatory reaction in liver tissue from patients with EHBA and Byler's disease, Methods: The expression of IH;A-DR and ICAM-1 and the number of CD4+, CD8+ and gamma/delta+ T-cells were investigated with immunoperoxidase technique on cryostat sections of liver tissue from patients with EHBA (n=11), Byler's disease (n=7) and (healthy controls (n=5), Results: Only mild inflammation was seen, mainly with CD4+ cells, predominantly in the portal tracts in EHBA and throughout the lobuli in Byler's disease, Neither ICAM-1 nor HLA-DR was present on the bile duct cells or hepatocytes in the control patients. The bile duct cells in all EHBA patients expressed both ICAM-1 and HLA-DR. HLA-DR was expressedon the hepatocytes in five EHBA patients, but ICAM-1 was only found on the hepatocytes in two EHBA patients: In Byler's disease the bile duct cells did not express ICAM-1 or HLA-DR, but the hepatocytes from all Byler patients expressed both ICAM-1 and HLA-DR. Conclusions: Although neither EHBA nor Byler's disease is characterized by intense inflammatory cell infiltration, an aberrant expression of ICAM-1 and HLA-DR was found in the liver in both patients with EHBA and patients with Byler's disease. The expression of HLA-DR and ICAM-1, was clearly distinct between the two disorders, indicating that it is not merely an unspecific event secondary to cholestasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 21:50:17