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Titolo:
Corticocortical associative neurons expressing latexin: Specific cortical connectivity formed in vivo and in vitro
Autore:
Arimatsu, Y; Ishida, M; Sato, M; Kojima, M;
Indirizzi:
Mitsubishi Kasei Inst Life Sci, Machida, Tokyo 1948511, Japan Mitsubishi Kasei Inst Life Sci Machida Tokyo Japan 1948511 1948511, Japan
Titolo Testata:
CEREBRAL CORTEX
fascicolo: 6, volume: 9, anno: 1999,
pagine: 569 - 576
SICI:
1047-3211(199909)9:6<569:CANELS>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SOMATOSENSORY CORTEX; SOMATIC SENSORY CORTEX; VISUAL-CORTEX; PROJECTION NEURONS; CEREBRAL-CORTEX; REGIONAL SPECIFICATION; LAMINAR ORGANIZATION; NEOCORTICAL AREAS; FRONTAL-CORTEX; MACAQUE MONKEY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Arimatsu, Y Mitsubishi Kasei Inst Life Sci, 11 Minamiooya, Machida, Tokyo 1948511, Japan Mitsubishi Kasei Inst Life Sci 11 Minamiooya Machida Tokyo Japan 1948511
Citazione:
Y. Arimatsu et al., "Corticocortical associative neurons expressing latexin: Specific cortical connectivity formed in vivo and in vitro", CEREB CORT, 9(6), 1999, pp. 569-576

Abstract

Latexin, a carboxypeptidase A inhibitor, is expressed in a subset of neurons in the infragranular layers of the lateral cortex in the rat. We here show that latexin-expressing neurons exhibit ultrastructural features common to cortical pyramidal neurons. We show in combined retrograde tracing and immunofluorescent experiments that latexin-expressing neurons contribute to specific cortico-cortical pathways. Thus, injections of the retrograde tracer fluorogold into either the primary somatosensory (SI) or the primary motor (MI) cortical area labeled many latexin expressing neurons in the infragranular layers of the secondary somatosensory (SII) and visceral sensory (Vi) areas. In contrast, tracer injections involving the thalamus, striatum, or contralateral SII and Vi exclusively labeled latexin-nonexpressing neurons in both the SII and Vi. Finally, we show that the correct corticocortical projections can be formed in organotypic slice cultures in vitro from latexin-expressing neurons: when slices of developing SII were cocultured withthose from the SI and the thalamus, latexin-immunoreactive neurons in the SII projected preferentially to their normal SI target. The specific connectivity formed in vivo and in vitro by this molecularly distinct neuronal population reveals its characteristic manner of cortical organization and provides a unique model system to analyze mechanisms underlying the formation of precise corticocortical pathways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:05:28