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Titolo:
Tissue lipid peroxidation and glutathione-dependent enzyme status in patients with oral squamous cell carcinoma
Autore:
Saroja, M; Balasenthil, S; Nagini, S;
Indirizzi:
Annamalai Univ, Fac Sci, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India Annamalai Univ Annamalainagar Tamil Nadu India 608002 , Tamil Nadu, India
Titolo Testata:
CELL BIOCHEMISTRY AND FUNCTION
fascicolo: 3, volume: 17, anno: 1999,
pagine: 213 - 216
SICI:
0263-6484(199909)17:3<213:TLPAGE>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIOXIDANT STATUS; CANCER PATIENTS; S-TRANSFERASES; FREE-RADICALS; CARCINOGENESIS; TOBACCO; TUMOR; PROLIFERATION; EXPRESSION;
Keywords:
oral cancer; lipid peroxidation; antioxidants; glutathione; glutathione peroxidase; glutathione transferase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Nagini, S Annamalai Univ, Fac Sci, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India Annamalai Univ Annamalainagar Tamil Nadu India 608002 du, India
Citazione:
M. Saroja et al., "Tissue lipid peroxidation and glutathione-dependent enzyme status in patients with oral squamous cell carcinoma", CELL BIOC F, 17(3), 1999, pp. 213-216

Abstract

We examined the extent of lipid peroxidation and the status of reduced glutathione (GSH) and the GSH-dependent enzymes - glutathione peroxidase (GPx)and glutathione-S-transferase (GST)- in oral tumour tissues from 33 adult oral cancer patients and an equal number of age- and sex-matched normal subjects. Diminished lipid peroxidation in the oral tumour tissue was accompanied by a significant decrease in phospholipids and an increase in the cholesterol/phospholipid (C/P) ratio. The concentration of glutathione and the activities of GPx and GST were elevated in oral tumour tissues. These findings suggest that GSH- and GSH-dependent enzymes play a crucial role in tobacco-related tumourigenesis and may be considered as markers of carcinogen exposure. Copyright (C) 1994 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 20:44:20