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Titolo:
INHIBITORY ACTIVITY OF 3'-FLUORO-2' DEOXYTHYMIDINE AND RELATED NUCLEOSIDE ANALOGS AGAINST ADENOVIRUSES IN-VITRO
Autore:
MENTEL R; KINDER M; WEGNER U; VONJANTALIPINSKI M; MATTHES E;
Indirizzi:
UNIV GREIFSWALD,INST MED MIKROBIOL,MARTIN LUTHER STR 6 D-17487 GREIFSWALD GERMANY MAX DELBRUCK CTR MOL MED D-13125 BERLIN GERMANY
Titolo Testata:
Antiviral research
fascicolo: 3, volume: 34, anno: 1997,
pagine: 113 - 119
SICI:
0166-3542(1997)34:3<113:IAO3DA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
2'-NOR-CYCLIC GMP; DNA POLYMERASE; VIRUS; INVITRO; 2',3'-DIDEOXYNUCLEOSIDES; REPLICATION; POTENT; BETA;
Keywords:
ADENOVIRUS; INHIBITION OF VIRUS REPLICATION; MODIFIED NUCLEOSIDE ANALOGS; FOCUS REDUCTION ASSAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
R. Mentel et al., "INHIBITORY ACTIVITY OF 3'-FLUORO-2' DEOXYTHYMIDINE AND RELATED NUCLEOSIDE ANALOGS AGAINST ADENOVIRUSES IN-VITRO", Antiviral research, 34(3), 1997, pp. 113-119

Abstract

Antiviral effects of nucleoside analogues against human adenoviruses (ADV) belonging to subgroup B (ADV3) and C (ADV2) were comparatively analysed using focus reduction assay on Fogh and Lund (FL) cells. 3'-Fluoro-2'-deoxythymidine (FTdR), 3'-fluoro-2'-deoxyuridine (FUdR), 2',3'-dideoxycytidine (ddC) and 3'-fluoro-2'-deoxyguanosine (FGdR) emerged as potent and selective inhibitors. They were nontoxic for the FL cells at the tested doses. FTdR was proved to be the most effective inhibitor against both serotypes ADV2 and ADV3 (0.05 mu M/0.02 mu M). The inhibitory effect of FTdR was also analyzed on the level of viral proteins and viral DNA synthesis using radioimmunoprecipitation and PCR, respectively. Neither the main structural protein of ADV, the hexon, nor viral DNA. could be detected in ADV-infected FL cells that had been exposed to FTdR. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:15:13