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Titolo:
Induction of melanoma in TPras transgenic mice
Autore:
Powell, MB; Gause, PR; Hyman, P; Gregus, J; Lluria-Prevatt, M; Nagle, R; Bowden, GT;
Indirizzi:
Univ Arizona, Arizona Canc Ctr, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 , Arizona Canc Ctr, Tucson, AZ 85724 USA
Titolo Testata:
CARCINOGENESIS
fascicolo: 9, volume: 20, anno: 1999,
pagine: 1747 - 1753
SICI:
0143-3334(199909)20:9<1747:IOMITT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALIGNANT SKIN MELANOMA; ULTRAVIOLET-RADIATION; MONODELPHIS-DOMESTICA; CUTANEOUS MELANOMA; RAS; MUTATIONS; GENE; TUMORIGENESIS; MELANOCYTES; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Powell, MB Univ Arizona, Arizona Canc Ctr, 1515 N Campbell Ave,POB 245042,Tucson, AZ85724 USA Univ Arizona 1515 N Campbell Ave,POB 245042 Tucson AZ USA 85724
Citazione:
M.B. Powell et al., "Induction of melanoma in TPras transgenic mice", CARCINOGENE, 20(9), 1999, pp. 1747-1753

Abstract

In order to study the oncogenesis of melanocytes, transgenic mouse lines were established that express a mutated human Ha-ras (TPras) gene in pigmentproducing cells, The ras transgenic mice exhibit an altered phenotype, including melanocytic hyperplasia and a muted agouti coat, indicative of hyperproliferative melanocytes. These mice and their wild-type littermates have been subjected to a variety of carcinogenesis protocols, including 7,12-dimethylbenz[a]anthracene (DMBA), 12-O-tetradecanoylphorbol-13-acetate (TPA) and UV radiation exposure. Topical DMBA treatment of TPras mice resulted in a high incidence of melanomas, Metastatic lesions were observed in skin, lungs and lymph nodes. TPA treatment of TPras mice induced a small number of papillomas but no nevi or melanomas, UV light exposures induced papillomas in negative littermate and melanomas in some albino TPras mice. These results show that melanocytes expressing an activated Ha-ras in the TPras transgenic mice are susceptible to induction of melanoma by DMBA.

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Documento generato il 04/12/20 alle ore 20:11:37