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Titolo:
Four new colon cancer susceptibility loci, Scc6 to Scc9 in the mouse
Autore:
van Wezel, T; Ruivenkamp, CAL; Stassen, APM; Moen, CJA; Demant, P;
Indirizzi:
Netherlands Canc Inst, Div Mol Genet, NL-1066 CX Amsterdam, Netherlands Netherlands Canc Inst Amsterdam Netherlands NL-1066 CX rdam, Netherlands
Titolo Testata:
CANCER RESEARCH
fascicolo: 17, volume: 59, anno: 1999,
pagine: 4216 - 4218
SICI:
0008-5472(19990901)59:17<4216:FNCCSL>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOMBINANT CONGENIC STRAINS; LINKAGE; TRAITS; GENES; TOOL; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Demant, P Netherlands Canc Inst, Div Mol Genet, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands Netherlands Canc Inst Plesmanlaan 121 Amsterdam Netherlands NL-1066 CX
Citazione:
T. van Wezel et al., "Four new colon cancer susceptibility loci, Scc6 to Scc9 in the mouse", CANCER RES, 59(17), 1999, pp. 4216-4218

Abstract

Germ-line mutations in APC and mismatch repair genes explain only a small percentage of all colorectal cancer cases. We have used the recombinant congenic strain mouse model to find new loci that are involved in the control of susceptibility to colon cancer. Five different colon cancer susceptibility genes, Scc1-Scc5, have been described previously using the recombinant congenic strains. Two of these loci, Scc4 and Scc5, show a reciprocal, genetic interaction. Here we report the mapping of four new colon tumor susceptibility genes: (a) Scc6 on chromosome 11; (b) Scc7 on chromosome 3; (c) Scc8on chromosome 8; and (d) Scc9 on chromosome 10. Scc7 and Seed show a genetic interaction; Scc7 is only detected by virtue of its interaction with Scc8.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 21:54:41