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Titolo:
In vivo occupancy of striatal and temporal cortical D-2/D-3 dopamine receptors by typical antipsychotic drugs - [I-123]-epidepride single photon emission tomography (SPET) study
Autore:
Bigliani, V; Mulligan, RS; Acton, PD; Visvikis, D; Ell, PJ; Stephenson, C; Kerwin, RW; Pilowsky, LS;
Indirizzi:
Inst Psychiat, London SE5 8AF, England Inst Psychiat London England SE5 8AF t Psychiat, London SE5 8AF, England Univ London Kings Coll, Sch Med, Inst Nucl Med, London WC2R 2LS, England Univ London Kings Coll London England WC2R 2LS London WC2R 2LS, England
Titolo Testata:
BRITISH JOURNAL OF PSYCHIATRY
, volume: 175, anno: 1999,
pagine: 231 - 238
SICI:
0007-1250(199909)175:<231:IVOOSA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRASTRIATAL D-2-DOPAMINE RECEPTORS; SCHIZOPHRENIC-PATIENTS; HUMAN-BRAIN; I-125 EPIDEPRIDE; PET; HALOPERIDOL; CLOZAPINE; BLOCKADE; BINDING; NEUROLEPTICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Pilowsky, LS Inst Psychiat, De Crespigny Pk, Denmark Hill, London SE5 8AF,England Inst Psychiat De Crespigny Pk, Denmark Hill London England SE5 8AF
Citazione:
V. Bigliani et al., "In vivo occupancy of striatal and temporal cortical D-2/D-3 dopamine receptors by typical antipsychotic drugs - [I-123]-epidepride single photon emission tomography (SPET) study", BR J PSYCHI, 175, 1999, pp. 231-238

Abstract

Background The dopamine hypothesis proposes that antipsychotic drugs act primarily through limbic cortical D-2/D-2-like dopamine receptor blockade. Aim To evaluate this hypothesis with the D-2/D-3-selective SPET probe [I-123]-epidepride. Method [I-123]-epidepride SPET scans were performed on 12 patients with schizophrenia treated with antipsychotics and 11 age- matched healthy controls. [I-123]-epidepride 'specific binding' to D-2/D-3 dopamine receptors was estimated, and relative percentage D-2/D-3 receptor occupancy by typical antipsychotic drugs determined. Results Mean (s.d.) daily dose was 669.12 (516.8) mg chlorpromazine equivalents. Mean percentage D-2/D-3, receptor occupancy was 81.6 (8.1) and 73.2 (13.9) in the temporal cortex and striatum respectively. Conclusions Typical antipsychotic drug treatment is associated with substantial temporal cortical D-2/D-3 receptor occupancy. The relationship between this and efficacy is poor in patients with treatment-resistant schizophrenia. Declaration of interest L.P. was supported by a Medical Research Council Clinician Scientist Fellowship. V.B. was supported by a research grant from Eli Lilly Pharmaceuticals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/11/19 alle ore 02:31:08