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Titolo:
The cannabinoid CB1 receptor antagonist, SR141716A, selectively facilitates nociceptive responses of dorsal horn neurones in the rat
Autore:
Chapman, V;
Indirizzi:
Univ Nottingham, Sch Med, Queens Med Ctr, Sch Biomed Sci, Nottingham NG7 2UH, England Univ Nottingham Nottingham England NG7 2UH , Nottingham NG7 2UH, England
Titolo Testata:
BRITISH JOURNAL OF PHARMACOLOGY
fascicolo: 8, volume: 127, anno: 1999,
pagine: 1765 - 1767
SICI:
0007-1188(199908)127:8<1765:TCCRAS>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPIOID RECEPTORS; SPINAL-CORD; HYPERALGESIA; POTENT; BRAIN;
Keywords:
nociception; spinal neurones; cannabinoid receptor antagonism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Chapman, V Univ Nottingham, Sch Med, Queens Med Ctr, Sch Biomed Sci, E Floor, Nottingham NG7 2UH, England Univ Nottingham E Floor Nottingham EnglandNG7 2UH UH, England
Citazione:
V. Chapman, "The cannabinoid CB1 receptor antagonist, SR141716A, selectively facilitates nociceptive responses of dorsal horn neurones in the rat", BR J PHARM, 127(8), 1999, pp. 1765-1767

Abstract

The effect of spinal administration of the selective cannabinoid CB1 receptor antagonist, SR141716A, and the selective CB2 receptor antagonist, SR144528, on innocuous versus noxious evoked responses of dorsal horn neurones in the spinal cord of the anaesthetized rat was investigated. SR141716A (0.001-l ng 50 mu 1(-1)) dose-relatedly facilitated the non-potentiated component of the electrical C-fibre mediated neuronal response (120 +/- 6, 156 +/-13, 192 +/- 33 and 192 +/- 31% of control respectively; n=6). In contrast,SR144528 (0.001-1 ng 50 mu 1(-1)) did not influence the non-potentiated component of the C-fibre evoked neuronal response (n=5). The electrical evoked A beta-fibre mediated neuronal responses were not influenced by SR141716Aor SR144528. The results of this study provide evidence that tonic cannabinoid CB1 receptor activation, but not CB2 receptor activation, attenuates acute nociceptive transmission, at the level of the spinal cord. These results suggest a selective antinociceptive role of the endogenous cannabinoids at spinal CB1 receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:01:53