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Titolo:
Circulating levels of endothelial function are modulated by dietary monounsaturated fat
Autore:
Perez-Jimenez, F; Castro, P; Lopez-Miranda, J; Paz-Rojas, F; Blanco, A; Lopez-Segura, F; Velasco, F; Marin, C; Fuentes, F; Ordovas, JM;
Indirizzi:
Hosp Univ Reina Sofia, Unidad Lipidos & Arteriosclerosis, Cordoba 14004, Spain Hosp Univ Reina Sofia Cordoba Spain 14004 clerosis, Cordoba 14004, Spain Hosp Univ Reina Sofia, Hematol Serv, Cordoba 14004, Spain Hosp Univ Reina Sofia Cordoba Spain 14004 tol Serv, Cordoba 14004, Spain Tufts Univ, USDA, Human Nutr Res Ctr Aging, Lipid Met Lab, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 Aging, Lipid Met Lab, Boston, MA 02111 USA
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 2, volume: 145, anno: 1999,
pagine: 351 - 358
SICI:
0021-9150(199908)145:2<351:CLOEFA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY-LIPOPROTEIN CHOLESTEROL; ACTIVATOR INHIBITOR TYPE-1; VON-WILLEBRAND-FACTOR; TISSUE FACTOR; PLASMINOGEN-ACTIVATOR; SERUM-CHOLESTEROL; IN-VIVO; PLASMA; ACID; ATHEROSCLEROSIS;
Keywords:
endothelial function; monounsaturated-rich diet; plasminogen activator inhibitor type 1; conjugated diene formation; plasma lipid profiles;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Perez-Jimenez, F Hosp Univ Reina Sofia, Unidad Lipidos & Arteriosclerosis,Avda Menendez Pidal S-N, Cordoba 14004, Spain Hosp Univ Reina Sofia Avda Menendez Pidal S-N Cordoba Spain 14004
Citazione:
F. Perez-Jimenez et al., "Circulating levels of endothelial function are modulated by dietary monounsaturated fat", ATHEROSCLER, 145(2), 1999, pp. 351-358

Abstract

Background: For the most part, the benefits of monounsaturated-rich diets (MUFA-diet) have been related to their action on plasma lipid levels. However other non-lipidic effects could also be involved in their protective effects. One of these involves the decrease in plasma levels of plasminogen activator inhibitor type 1 (PAI-1), the main inhibitor of fibrinolysis. Giventhat the PAI-1 is of endothelial origin, one hypothesis is that the MUFA-diet could protect against CHD by modulating some endothelial components. Methods and results: Healthy male subjects (n = 25) received three different consecutive diets, each lasting 28 days: a low fat NCEP-I-diet, with 28% calories as fat, 10% saturated fat (SAT), 12% monounsaturated (MUFA) and 6% polyunsaturated (PUFA); a MUFA-diet, with 38% calories as fat, 10% SAT, 22% MUFA and 6% PUFA, and a SAT rich-diet (SAT-diet), with 38% calories as fat,20% SATI 12% MUFA and 6% PUFA. After each dietary period, the plasma lipidprofile was determined. including total cholesterol, HDL cholesterol, LDL cholesterol. total triglyceride, apo Al. apo B plasma levels and conjugateddiene formation, after incubation of LDL particles with Cu 5 mu M/l. Endothelial products measured in plasma were von Willebrand factor (VWF), E-selectin, Thrombomodulin and Tissue Factor Pathway Inhibitor (TFPI) levels. We observed a decrease in VWF, PAI-1 and TFPI plasma levels and an increase inlag time of conjugated diene formation after the MUFA-diet. There was a positive correlation between the decreases in TFPI and VWF and the changes intotal cholesterol, LDL-C, apo B plasma levels. The decrease in TFPI was negatively correlated with the increase in lag time of conjugated diene formation. PAI-1 plasma levels were positively correlated with total cholesterol, LDL-C and triglycerides and negatively correlated with HDL-C. Conclusions: Consumption of a Mediterranean-type MUFA-diet produces a decrease in plasma levels of vWF, TFPI and PAI-1 plasma levels in young healthy males. Given that these substances are of endothelial origin, one could suggest that the MUFA of the diet has a beneficial effect on endothelial function resulting in protective changes against thrombogenesis. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 17:58:08