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Titolo:
Vasculo-protective effects of insulin sensitizing agent pioglitazone in neointimal thickening and hypertensive vascular hypertrophy
Autore:
Yoshimoto, T; Naruse, M; Shizume, H; Naruse, K; Tanabe, A; Tanaka, M; Tago, K; Irie, K; Muraki, T; Demura, H; Zardi, L;
Indirizzi:
Tokyo Womens Med Univ, Dept Med, Inst Clin Endocrinol, Shinjuku Ku, Tokyo 162, Japan Tokyo Womens Med Univ Tokyo Japan 162 nol, Shinjuku Ku, Tokyo 162, Japan Tokyo Womens Med Univ, Dept Pharmacol, Tokyo 162, Japan Tokyo Womens Med Univ Tokyo Japan 162 , Dept Pharmacol, Tokyo 162, Japan Inst Nazl Ricerca Cancro, Cell Biol Lab, Genoa, Italy Inst Nazl Ricerca Cancro Genoa Italy ancro, Cell Biol Lab, Genoa, Italy
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 2, volume: 145, anno: 1999,
pagine: 333 - 340
SICI:
0021-9150(199908)145:2<333:VEOISA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; RESISTANCE VESSELS; RATS; TROGLITAZONE; GROWTH; HYPERPLASIA; PHENOTYPE; RECEPTOR; EXPRESSION; METABOLISM;
Keywords:
thiazolidine; pioglitazone; vascular smooth muscle cell; neointima formation; hypertension; fibronectin; morphometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Yoshimoto, T Tokyo Womens Med Univ, Dept Med, Inst Clin Endocrinol, Shinjuku Ku, 8-1 Kawadacho, Tokyo 162, Japan Tokyo Womens Med Univ 8-1 Kawadacho Tokyo Japan 162 2, Japan
Citazione:
T. Yoshimoto et al., "Vasculo-protective effects of insulin sensitizing agent pioglitazone in neointimal thickening and hypertensive vascular hypertrophy", ATHEROSCLER, 145(2), 1999, pp. 333-340

Abstract

A novel insulin sensitizing agent, thiazolidine, has been demonstrated to inhibit the growth of cultured vascular smooth muscle cells (VSMC) in vitro. This study was undertaken to examine the in vivo effects of the thiazolidine compound pioglitazone (PIO) on carotid neointimal thickening, after endothelial injury in Wistar rats and vascular hypertrophy in stroke-prone spontaneously hypertensive rats (SHR-SP/Izm). PIO treatment (3 mg/kg/day for 1week prior to endothelial injury and 2 weeks postendothelial injury) remarkably decreased neointimal cross-sectional areas in treated animals (63.8 +/- 4.9 x 10(3) mu m(2)) versus controls (196 +/- 7.6 x 10(3) mu m(2), P < 0.05). Bromodeoxyuridine uptake in the neointima, a marker of DNA synthesis,was also decreased after treatment compared with controls. In SHR-SP/Izm but not in Wistar rats, PIO treatment decreased blood pressure and plasma insulin levels. PIO treatment in SHR-SP/Izm (3 mg/kg/day from 4 weeks of age for 7 weeks) significantly decreased the medial wall thickness of the mesenteric artery (10.4 +/- 1.2 x 10(3) mu m(2) versus control, 21.2 +/- 2.4 x 10(3) mu m(2), P < 0.05). In addition, PIO treatment significantly decreasedthe expression of EIIIA fibronectin both in the carotid neointima of Wistar rats and the media of the mesenteric artery in SHR-SP/Izm compared with their respective controls (P < 0.05). These results suggest that PIO has vasculo-protective effects in both acute and chronic vascular injury in vivo through inhibition of VSMC proliferation. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 15:05:15