Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A unitary model of schizophrenia - Bleuler's "fragmented phrene" as schizencephaly
Autore:
Andreasen, NC;
Indirizzi:
Univ Iowa Hosp & Clin, Mental Hlth Clin Res Ctr, Iowa City, IA 52242 USA Univ Iowa Hosp & Clin Iowa City IA USA 52242 Ctr, Iowa City, IA 52242 USA
Titolo Testata:
ARCHIVES OF GENERAL PSYCHIATRY
fascicolo: 9, volume: 56, anno: 1999,
pagine: 781 - 787
SICI:
0003-990X(199909)56:9<781:AUMOS->2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; DORSOLATERAL PREFRONTAL CORTEX; NEUROLEPTIC-NAIVE PATIENTS; FIRST-EPISODE SCHIZOPHRENIA; PRACTICED FREE-RECALL; BASAL GANGLIA; COGNITIVE DYSMETRIA; PHYSIOLOGICAL DYSFUNCTION; STRUCTURAL ABNORMALITIES; CEREBELLAR CONTRIBUTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
96
Recensione:
Indirizzi per estratti:
Indirizzo: Andreasen, NC Univ Iowa Hosp & Clin, Mental Hlth Clin Res Ctr, 2911 JPP,200 Hawkins Dr, Iowa City, IA 52242 USA Univ Iowa Hosp & Clin 2911 JPP,200 Hawkins Dr Iowa City IA USA 52242
Citazione:
N.C. Andreasen, "A unitary model of schizophrenia - Bleuler's "fragmented phrene" as schizencephaly", ARCH G PSYC, 56(9), 1999, pp. 781-787

Abstract

Finding a unifying concept behind the diversity of signs and symptoms in schizophrenia is a central challenge to contemporary research. A neo-Bleulerian unitary model is described, which defines the illness as a neurodevelopmentally derived "misconnection syndrome," involving connections between cortical regions and the cerebellum mediated through the thalamus (the cortico-cerebellar-thalamic-cortical circuit [CCTCC]). An abnormality in this circuitry, normally used to coordinate both motor and mental activity, leads to misconnections in many aspects of mental activity, or "cognitive dysmetria. " As Bleuler originally proposed, "thought disorder" is the primary defining feature of schizophrenia, rather than the more obvious signs and symptoms such as delusions and hallucinations. Cognitive dysmetria, or a disorderin the CCTCC, may provide a heuristic theoretical framework for strategiesto explore etiology, pathophysiology, intervention, or prevention.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:54:44