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Titolo:
Decreased serum biochemical markers of muscle origin in patients with ankylosing spondylitis
Autore:
Giltay, EJ; van Schaardenburg, D; Gooren, LJG; Kostense, PJ; Dijkmans, BAC;
Indirizzi:
Univ Hosp Vrije Univ, Div Androl, Dept Endocrinol, Inst Endocrinol Reprod & Metab, NL-1007 MB Amsterdam, Netherlands Univ Hosp Vrije Univ AmsterdamNetherlands NL-1007 MB erdam, Netherlands Univ Hosp Vrije Univ, Dept Rheumatol, NL-1007 MB Amsterdam, Netherlands Univ Hosp Vrije Univ Amsterdam Netherlands NL-1007 MB erdam, Netherlands Univ Hosp Vrije Univ, Dept Clin Epidemiol & Biostat, NL-1007 MB Amsterdam,Netherlands Univ Hosp Vrije Univ Amsterdam Netherlands NL-1007 MB terdam,Netherlands Jan Van Breemen Inst, Dept Rheumatol, Amsterdam, Netherlands Jan Van Breemen Inst Amsterdam Netherlands atol, Amsterdam, Netherlands
Titolo Testata:
ANNALS OF THE RHEUMATIC DISEASES
fascicolo: 9, volume: 58, anno: 1999,
pagine: 541 - 545
SICI:
0003-4967(199909)58:9<541:DSBMOM>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CREATINE-KINASE ACTIVITY; TESTOSTERONE; PREDICTION; STRENGTH; DISEASE; LIVER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Giltay, EJ Univ Hosp Vrije Univ, Div Androl, Dept Endocrinol, Inst Endocrinol Reprod & Metab, POB 7057, NL-1007 MB Amsterdam, Netherlands Univ Hosp Vrije Univ POB 7057 Amsterdam Netherlands NL-1007 MB
Citazione:
E.J. Giltay et al., "Decreased serum biochemical markers of muscle origin in patients with ankylosing spondylitis", ANN RHEUM D, 58(9), 1999, pp. 541-545

Abstract

Objectives-There is a lack of unanimity about (increased) serum levels of creatine kinase (CK) in patients with ankylosing spondylitis (AS), perhaps because of the inclusion of inappropriate controls. Therefore, serum levelsof biochemical markers of muscle origin were assessed in AS patients compared with controls. Methods-In a comparative study serum levels of sarcoplasmic proteins indicating muscle cell leakage, creatinine, and C reactive protein (CRP) were measured. Fifty eight AS patients with a mean disease duration of 22 (SD 11) years and 58 age and sex matched controls (without back complaints) were included. Results-Lower serum levels in AS patients compared with controls were found for CK (mean (SD): 46 (21) v 76 (44) IU/l; p<0.001), aldolase (0.43 (0.36) v 0.58 (0.32) IU/l; p=0.001), creatinine (91 (13) v 96 (11) mu mol/l; p=0.02), alanine aminotransferase (2.8 (1.5) v 4.1 (2.9) IU/l; p=0.001) and aspartate aminotransferase (7.0 (2.7) v 8.4 (3.5) IU/l; p=0.02). Also the lean body mass, as estimated by a formula using height, weight, age and sex, showed lower values in patients versus controls (56 (9) v 59 (9) kg; p=0.004), but creatinine clearance (by Cockcroft and Gault formula) was not different (p=0.48). Partial correlation coefficients adjusted for age and sex showed that CRP levels correlated negatively with CK and aldolase levels in ASpatients (r=-0.48, p<0.001 and r=-0.37, p=0.005, respectively). Conclusion-Serum levels of biochemical markers of muscle origin were lowerin AS patients compared with controls. Patients with active AS, as reflected by high CRP levels, may have an increased protein degradation, predominantly in skeletal muscle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 14:56:04