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Titolo: CAENORHABDITIS-ELEGANS CDNA FOR A MENKES WILSON-DISEASE GENE HOMOLOG AND ITS FUNCTION IN A YEAST CCC2 GENE DELETION MUTANT/
Autore: SAMBONGI Y; WAKABAYASHI T; YOSHIMIZU T; OMOTE H; OKA T; FUTAI M;
- Indirizzi:
- OSAKA UNIV,INST SCI & IND RES,DEPT BIOL SCI,8-1 MIHOGAOKA IBARAKI OSAKA 567 JAPAN OSAKA UNIV,INST SCI & IND RES,DEPT BIOL SCI IBARAKI OSAKA 567 JAPAN
- Titolo Testata:
- Journal of Biochemistry
fascicolo: 6,
volume: 121,
anno: 1997,
pagine: 1169 - 1175
- SICI:
- 0021-924X(1997)121:6<1169:CCFAMW>2.0.ZU;2-Q
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- COPPER-TRANSPORTING ATPASE; P-TYPE ATPASES; WILSON-DISEASE; CANDIDATE GENE; MENKES DISEASE; MEMBRANE-VESICLES; SACCHAROMYCES-CEREVISIAE; ENTEROCOCCUS-HIRAE; SECRETORY PATHWAY; VACUOLAR MEMBRANE;
- Keywords:
- CAENORHABDITIS ELEGANS; COPPER TRANSPORTING ATPASE; IMMUNOFLUORESCENCE MICROSCOPY; MENKES/WILSON DISEASE GENE HOMOLOG; YEAST CCC2 GENE;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Citazioni:
- 42
- Recensione:
- Indirizzi per estratti:
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- Citazione:
- Y. Sambongi et al., "CAENORHABDITIS-ELEGANS CDNA FOR A MENKES WILSON-DISEASE GENE HOMOLOG AND ITS FUNCTION IN A YEAST CCC2 GENE DELETION MUTANT/", Journal of Biochemistry, 121(6), 1997, pp. 1169-1175
Abstract
The full-length cDNA coding for a putative copper transporting P-typeATPase (Cu2+-ATPase) was cloned from Caenorhabditis elegans, The putative Cu2+-ATPase is a 1,238-amino acid protein, and highly homologous to the Menkes and Wilson disease gene products mutations of which are responsible for human defects of copper metabolism, The Saccharomyces cerevisiae mutant with a disrupted CCC2 gene (yeast Menkes/Wilson disease gene homologue) was rescued by the cDNA for the C. elegans Cu2+-ATPase but not by the cDNA with an Asp-786 (an invariant phosphorylationsite) to Asn mutation, suggesting that the C. elegans Cu2+-ATPase functions as a copper transporter in yeast, The expressed C. elegans protein was detected in yeast vacuolar membranes by immunofluorescence microscopy. The yeast expression system may facilitate further studies oncopper transporting P-type ATPases.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:06:01