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Titolo:
Use of factor-analyzed symptom of dimensions to predict outcome with serotonin reuptake inhibitors and placebo in the treatment of obsessive-compulsive disorder
Autore:
Mataix-Cols, D; Rauch, SL; Manzo, PA; Jenike, MA; Baer, L;
Indirizzi:
Univ Barcelona, Dept Psiquiatra & Psicobiol Clin, E-08035 Barcelona, SpainUniv Barcelona Barcelona Spain E-08035 ol Clin, E-08035 Barcelona, Spain Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Psychiat, Boston, MA 02114 USA Harvard Univ, Sch Med, Boston, MA USA Harvard Univ Boston MA USAHarvard Univ, Sch Med, Boston, MA USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 9, volume: 156, anno: 1999,
pagine: 1409 - 1416
SICI:
0002-953X(199909)156:9<1409:UOFSOD>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC TIC DISORDER; DOUBLE-BLIND; BEHAVIORAL TREATMENT; CONTROLLED TRIAL; TREATMENT RESPONSE; CLOMIPRAMINE; PERSONALITY; FLUVOXAMINE; FLUOXETINE; SUBTYPES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Mataix-Cols, D Univ Barcelona, Dept Psiquiatra & Psicobiol Clin, Passeig de la Vail dHebron 171, E-08035 Barcelona, Spain Univ Barcelona Passeig de la Vail dHebron 171 Barcelona Spain E-08035
Citazione:
D. Mataix-Cols et al., "Use of factor-analyzed symptom of dimensions to predict outcome with serotonin reuptake inhibitors and placebo in the treatment of obsessive-compulsive disorder", AM J PSYCHI, 156(9), 1999, pp. 1409-1416

Abstract

Objective: No consistent predictors of outcome have been identified for the pharmacotherapy of obsessive-compulsive disorder (OCD). Recent factor analytic studies have identified meaningful symptom dimensions that may be related to response to serotonin reuptake inhibitors and other treatments. Method: A total of 354 outpatients with primary OCD were administered the Yale-Brown Obsessive Compulsive Scale Symptom Checklist, and its 13 main symptom categories were factor analyzed by using principal components analysis. The identified symptom dimensions were then entered into multiple regressionmodels as outcome predictors of response to serotonin reuptake inhibitors and placebo response in a group of 150 nondepressed subjects who completed six double-blind, placebo-controlled trials with a serotonin reuptake inhibitor (clomipramine, fluvoxamine, fluoxetine, sertraline, and paroxetine). Eighty-four patients received a serotonin reuptake inhibitor and 66, placebo. Results: The principal components analysis identified five factors that explained 65.5% of variance in outcome: symmetry/ordering, hoarding, contamination/cleaning, aggressive/checking, and sexual/religious obsessions. Serotonin reuptake inhibitors were significantly superior to placebo on all outcome measures. Initial severity of OCD was related to greater posttreatmentseverity of OCD. Higher scores on the hoarding dimension predicted poorer outcome following treatment with serotonin reuptake inhibitors, after control for baseline severity. No predictors of placebo response were identified. Exclusion of clomipramine did not modify the overall results, suggesting a cross-serotonin reuptake inhibitor effect. Conclusions: The identified symptom dimensions are largely congruent with those identified in earlier reports. Patients with OCD vary in their response to treatment with serotonin reuptake inhibitors. The presence of hoarding obsessions and compulsions isassociated with poorer response to serotonin reuptake inhibitors.

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Documento generato il 13/07/20 alle ore 06:23:38