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Titolo:
Tissue-specific changes in RNA synthesis in vivo during anoxia in crucian carp
Autore:
Smith, RW; Houlihan, DF; Nilsson, GE; Alexandre, J;
Indirizzi:
Univ Aberdeen, Dept Zool, Aberdeen AB24 2TZ, Scotland Univ Aberdeen Aberdeen Scotland AB24 2TZ ol, Aberdeen AB24 2TZ, Scotland Univ Oslo, Dept Gen Physiol, N-0316 Oslo, Norway Univ Oslo Oslo Norway N-0316 Oslo, Dept Gen Physiol, N-0316 Oslo, Norway Cell Physiol, F-35042 Rennes, France Cell Physiol Rennes France F-35042Cell Physiol, F-35042 Rennes, France
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 3, volume: 46, anno: 1999,
pagine: R690 - R697
SICI:
0363-6119(199909)46:3<R690:TCIRSI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-SYNTHESIS; NUCLEOSIDE TRANSPORT; ONCORHYNCHUS-MYKISS; URIDINE UPTAKE; RAINBOW-TROUT; MESSENGER-RNA; ANIMAL-CELLS; LIVER; NUCLEOTIDES; ISCHEMIA;
Keywords:
precursor-dependent RNA synthesis; nucleotide salvage; fixed pretranslational energy cost;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, RW Commiss European Communities, Joint Res Ctr, Inst Environm, CCR,TP 460, I-21020 Ispra, VA, Italy Commiss European Communities TP 460 IspraVA Italy I-21020 Italy
Citazione:
R.W. Smith et al., "Tissue-specific changes in RNA synthesis in vivo during anoxia in crucian carp", AM J P-REG, 46(3), 1999, pp. R690-R697

Abstract

The overall energy budget for protein synthesis (i.e., transcription plus translation) is thought to consist of fixed and variable components, with RNA synthesis accounting for the former and protein synthesis the latter. During anoxia, the downregulation of protein synthesis (i.e., the variable component), to reduce energetic demand, is an important aspect of survival incrucian carp. The present study examines RNA synthesis during anoxia by labeling with [H-3]uridine. A novel synthesis rate calculation is presented, which allows for the tissue-specific salvage of uridine, with synthesis rates finally expressed relative to DNA. After 48 h anoxia, the decline (29%) in brain RNA synthesis and increases in the heart and liver (132 and 871%, respectively) support known RNA functions during hypoxic/anoxic survival. This study provides evidence that, in an anoxia-tolerant species, survival mechanisms involving RNA are able to operate because tissue-specific restructuring of the RNA synthesis process enables fixed synthesis costs to be maintained; this may be as vital to survival as exploiting the variable energetic demand of protein synthesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:54:37